Nutritional and Dietary Management of Chronic Kidney Disease Under Conservative and Preservative Kidney Care Without Dialysis

While dialysis has been the prevailing treatment paradigm for patients with advanced chronic kidney disease (CKD), emphasis on conservative and preservative management in which dietary interventions are a major cornerstone have emerged. Based on high-quality evidence, international guidelines support the utilization of low-protein diets as an intervention to reduce CKD progression and mortality risk, although the precise thresholds (if any) for dietary protein intake vary across recommendations. There is also increasing evidence demonstrating that plant-dominant low-protein diets reduce the risk of developing incident CKD, CKD progression, and its related complications including cardiometabolic disease, metabolic acidosis, mineral and bone disorders, and uremic toxin generation. In this review, we discuss the premise for conservative and preservative dietary interventions, specific dietary approaches used in conservative and preservative care, potential benefits of a plant-dominant low-protein diet, and practical implementation of these nutritional strategies without dialysis.


Introduction: Scope and International Trends of Advanced Chronic Kidney
2][3][4][5] Nearly four million people in the world have end-stage kidney disease (ESKD) treated with kidney replacement therapy, with the majority (69%) receiving hemodialysis. 6With respect to international comparisons, the United States incidence rate (410 per million) trails closely behind that of parts of Mexico (570 and 483 per million in Jalisco and Aguascalientes, respectively) and Taiwan (529 per million) as the geographic catchments with the highest rates of de novo ESKD. 7ternational data also show an aging and ailing incident ESKD population worldwide. 7- 9Across Western high income countries, age-stratified analyses show that the highest incidence of treated ESKD is among patients ≥75 years of age. 7Data from the National Institutes of Health sponsored "Transitions of Care in CKD" United States Renal Data System Special Study have also shown that, among people living with advanced CKD transitioning to ESKD, there is a high burden of comorbidities, including diabetes (74%), heart failure (59%), depression (33%), and anxiety (10%), 10 as well as symptom burden. 2,11,12While dialysis has been the prevailing treatment paradigm among patients with advanced CKD who are ineligible for, or unlikely to, receive preemptive kidney transplantation, there has been growing emphasis on conservative and preservative measures.2][3][4] In this review, we discuss 1) the rationale for conservative and preservative dietary management approaches, 2) specific dietary interventions in the conservative and preservative care of advanced CKD, 3) potential benefits of a low-protein and plant-dominant diet, including data on kidney, metabolic, and survival outcomes, and 4) the practical implementation of dietary interventions in conservative and preservative care.

Revisiting Traditional Paradigms in the Management of Advanced CKD
For approximately 5 decades, dialysis has been the default treatment strategy for ESKD globally.In 1972, the United States Congress approved the 1972 Medicare End-Stage Renal Disease Program which ended rationing of dialysis due to limited resources and led to near-universal access to this form of renal replacement therapy. 14However, an unintended consequence of uninhibited access to dialysis has been the limited progress and innovation in alternative dialysis-free treatment strategies of ESKD until recently. 3,4ltiple studies show that dialysis, while life-extending, may not always exert the intended effect of restoring health nor improving outcomes in patients with advanced nondialysis dependent (NDD) CKD who are transitioning to ESKD.6][17] Furthermore, incident patients with ESKD transitioning to dialysis may exhibit frequent hospitalizations and readmissions, lower HRQOL, loss of independence, decline in physical function, increased symptom burden, and higher healthcare costs. 3,4,18Furthermore, large multicenter trial data did not show that planned early initiation of dialysis conferred improved survival nor clinical outcomes as compared with late-start dialysis. 19,20Recognizing these limitations of dialysis therapy, the federally mandated Advancing American Kidney Health Initiative unveiled in 2019 has recommended the adoption of treatments that slow or stop CKD progression, 21,22 which has elevated the role of conservative and preservative management to the forefront of clinical care.

Concept of Conservative and Preservative Management
The concept of conservative and preservative management is centered on providing 1) active and comprehensive medical management of advanced CKD using nondialytic strategies and 2) ameliorating CKD progression, with the primary objectives of a) optimizing HRQOL, b) treating symptoms and complications of ESKD without dialysis or kidney transplantation, and c) preserving residual kidney function. 3,4It should also be clarified that conservative and preservative care do not equate to "no care" or "rationing of care," and in fact require a multifaceted and holistic approach in which dietary interventions are a major cornerstone in management (Figure 1).Below we discuss the rationale for specific dietary interventions in conservative and preservative care, including 1) low dietary protein intake, largely from plant-dominant protein sources, 2) higher fruit and vegetable consumption, 3) increased dietary fiber intake, and 4) maintaining adequate caloric intake.

Low-Protein Diets in Conservative and Preservative Management Clinical Practice Guidelines and Scientific Premise for Low-Protein Diets
In 2020, the National Kidney Foundation and Academy of Nutrition and Dietetics with endorsement from the International Society of Renal Nutrition and Metabolism (ISRNM) released an update to the Kidney Disease Outcomes Quality Initiative (KDOQI) Clinical Practice Guidelines for Nutrition in CKD (Table 1). 235][26][27] More specifically, the KDOQI guidelines advise that adults with stages 3 to 5 NDD-CKD without diabetes who are metabolically stable should consume 1) a low-protein diet of 0.55-0.60g/kg body weight/day, or 2) a very-low-protein diet of 0.28-0.43g/kg of body weight/day with additional keto acid analogs in order to reduce risk of ESKD and/or death and to improve HRQOL based on grade 1A and 2C evidence.Among adults with stages 3 to 5 NDD-CKD with diabetes, the KDOQI guidelines also indicate that it is reasonable to prescribe a lower dietary protein intake of 0.6 to 0.8 g/kg of body weight/day to maintain stable nutritional status and optimize glycemic control based on opinion-level evidence.However, it bears mention that the guidelines were based on randomized controlled trials (RCTs) only and did not include implementation studies.Furthermore, while the evidence on patients with NDD-CKD is scant, in spite of very few RCTs, large observational studies were not taken into consideration.
Although the ISRNM, the largest international nutritional organization for the kidney disease population, was not directly involved in formulating the updated 2020 KDOQI guidelines, multiple ISRNM members led and/or played prominent roles in the guideline development, and the ISRNM also convened a review panel of international experts evaluating the recommendations prior to public review. 28Following public release of the 2020 KDOQI guidelines, the ISRNM and international kidney nutrition leaders published a commentary following a review and critical analysis in support of the updated recommendations. 28The ISRNM commentary included one notable distinction from the updated KDOQI guidelines.ISRNM experts highlighted that it is reasonable for clinicians to aim for the lower end of a streamlined target of 0.6 to 0.8 g/kg/day regardless of CKD etiology, considering that 1) lower dietary protein targets (i.e., 0.28-0.43g/kg/day) may be challenging to achieve, particularly in geographic catchments without access to keto acid analogs and/or kidney dietitians, and 2) in the low dietary protein trials, actual dietary protein intake was generally above 0.6 g/kg/day despite a prescribed target of 0.55 to 0.6 g/kg/day (Table 2).
It bears mention that large population-based data show a high intake of dietary protein among adults across all levels of kidney function.In a cross-sectional analysis of 16,872 adults from that National Health and Nutrition Examination Survey (NHANES) who underwent dietary protein intake assessment by 24-hour dietary recall, mean dietary protein intake among both participants with and without kidney dysfunction was higher than recommended guidelines for NDD-CKD by KDOQI and for healthy adults by the Institute of Medicine, respectively. 29These trends are not surprising given the popularity of various high-protein diets in secular culture as a means of countering obesity and dysglycemia 30 and/or marketing trends to enhance products with added protein.[35]

Data on the Efficacy/Effectiveness and Safety of Low-Protein Diets
7][38][39][40] For example, in a meta-analysis of 16 RCTs of low dietary protein intake in NDD-CKD, pooled data showed that lower protein intake of <0.8 g/kg/day was associated with lower risk of ESKD and all-cause mortality.The meta-analysis also demonstrated improved biochemical parameters including higher serum bicarbonate levels, decreased serum phosphorus levels, and less azotemia, as compared with a dietary protein intake of ≥0.8 g/kg/day. 402][43] Other clinical trials and observational studies have corroborated the benefits of low-protein diets on CKD outcomes [36][37][38][39] and survival. 44e safety of low-protein diets in NDD-CKD has also been corroborated by clinical trial and observational data.In a meta-analysis of 7 RCTs of low-protein diets supplemented with keto acid analogs in NDD-CKD, compared with a normal protein diet, supplemented lowprotein or very-low protein diets prevented eGFR decline without leading to differences in serum albumin, serum creatinine, nor other nutrition indices across different protein intake groups. 39A more recent meta-analysis of 17 NDD-CKD trials comparing low-protein diets supplemented with keto acid analogs versus regular diets or nonsupplemented low-protein diets showed that supplemented low-protein diets significantly preserved eGFR and reduced proteinuria, increased serum albumin, and demonstrated no differences in other nutritional indices (e.g., body mass index, skinfold thickness, mid-arm circumference, and lean body mass). 37The safety and efficacy of low-protein diets have also been observed in patients with NDD-CKD of older age. 35In a landmark RCT of older (>70 years) adults with advanced NDD-CKD (eGFR 5-7 mL/minute/1.73m 2 ) without diabetes in Italy who were randomized to a supplemented very-low protein vegan diet (comprised of dietary protein intake of 0.3 g/kg/day and keto acids, amino acids, and vitamins) versus dialysis without dietary protein intake restriction, those in the supplemented very-low protein vegan diet arm delayed dialysis by ~11 months, with both groups showing similar mortality rates and the dialysis group demonstrating higher rates of hospitalization. 369][50] Furthermore, although there are misconceptions that elderly patients with CKD typically have spontaneous reduction in dietary protein intake thereby making low-protein diets (LPDs) futile in this context, clinical studies have shown that most elderly patients consume higher-than-recommended dietary protein intake 51 ; hence, there is indeed need for personalized nutritional management in this subpopulation. 51,52dditionally, a consensus paper from the European Society for Clinical Nutrition and Metabolism and the European Renal Nutrition group of the European Renal Association has underscored that individual risk-benefit assessment and appropriate nutritional monitoring should guide clinical decision-making in elderly patients with CKD. 52There has also been growing emphasis on the avoidance of excessive restriction and the optimization of the palatability and overall quality of life with more patient-centered dietary approaches.For example, long-term follow-up data from the TOrina-Pisa study showed high dietary satisfaction and minimal dropout among stages 3 to 5 patients with NDD-CKD who underwent moderately restricted LPDs (0.6 g/kg/day). 53This was also corroborated in a study of 153 patients with stages 3 to 5 NDD-CKD from France and Italy who underwent a personalized approach toward protein restriction. 54

Plant-Dominant Diets in Conservative and Preservative Management Clinical Practice Guidelines and Scientific Premise
6][57] While the 2020 KDOQI guidelines indicate insufficient evidence to recommend a particular type of protein (plant vs. animal), the updated recommendations do support prescribing greater fruit and vegetable intake in patients with stages 1 to 4 NDD-CKD in order to decrease body weight, blood pressure, and net acid production. 23Whereas the KDOQI guidelines relied heavily on RCT data to limit risk of bias, the ISRNM commentary advised that an increasing number of observational data and clinical trials published following the KDOQI guidelines support plant-based protein and/or dietary patterns that may be reasonable for clinicians to consider. 28

Evidence of Efficacy/Effectiveness
Multiple observational studies have demonstrated that plant-based protein sources are associated with decreased risk of incident and prevalent CKD, CKD progression, and mortality risk.In a cross-sectional analysis of 420 adults with type 2 diabetes from the Dutch DIAbetes and LifEstyle Cohort Twente-1 cohort, participants completed food frequency questionnaires (FFQs) of the amounts of vegetable versus animal protein intake.Among participants with a dietary protein consumption of <0.8 g/kg/day, those with greater intake of protein from vegetable sources (defined as the highest tertile of vegetable protein intake) had a lower likelihood of prevalent CKD. 58With respect to developing de novo CKD, a longitudinal study of 11,952 Atherosclerosis Risk in Communities study participants with normal baseline kidney function completed two FFQ assessments over a median follow-up of 23 years.Participants with greater consumption of red and processed meats had higher risk of incident CKD, whereas those with higher dietary intake of nuts, legumes, and low-fat dairy had lower risk of developing CKD. 59Longitudinal data from the Nurses Health Study has also shown that both protein amount and source have a bearing on CKD progression. 60In 1624 women who completed semiquantitative FFQ's, among those who had mild kidney dysfunction (eGFR's ≥ 55-<80 mL/minute/1.73m 2 ) followed over 11 years, both higher dietary protein intake and intake from nondairy animal protein sources (as opposed to vegetable and dairy protein sources) were each associated with greater decline in eGFR over time.In a more recent observational study of 27,604 participants from the NHANES who underwent 24-hour dietary recall, both higher dietary protein intake of ≥1.4 g/kg/day compared to lower intake of 0.6 to <1.0 g/kg/day and intake from high biological value sources (i.e., sources with an amino acid composition similar to human proteins, which are typically from animal sources) were each associated with higher mortality risk. 44][63][64][65] Longitudinal data from a study of 449 patients with NDD-CKD from Italy who underwent moderately restricted LPDs have also shown that this dietary intervention leads to longer dialysis-free follow-up time with comparable survival to dialysis at a lower cost. 66 addition to the aforementioned Brunori et al. study, 36 a growing number of clinical trials have also examined the effects of plant-based diets in NDD-CKD.An RCT of 41 patients with diabetic kidney disease examined the effect of a soy protein diet (comprised of 65% soy/vegetable proteins and 35% animal proteins) versus a control diet (comprised of 70% animal protein and 30% vegetable protein).Participants in the soy protein arm demonstrated a significant reduction in proteinuria, glucose, lipids, and inflammatory marker levels over a 4-year follow-up period. 67In another trial of nondiabetic NDD-CKD with eGFR <30 mL/ minute/1.73m 2 without substantial proteinuria (<1 g/g urinary creatinine), 207 participants were randomized to a keto acid analog supplemented vegetarian very-low-protein diet (0.3 g/kg/day of vegetable proteins) versus a conventional low-protein diet (0.6 g/kg/day).The study demonstrated that the supplemented vegetarian very-low protein diet was nutritionally safe and led to deferral of dialysis initiation. 68

Not All Plant-Based Diets are Low-Protein Diets
While various plant-based or plant-dominant diets (Table 2) including the DASH and Mediterranean diets confer a number of salutary benefits, it is important to highlight that they are not all per se low-protein diets. 69In a cross-sectional study of 71,851 participants in the Adventist Health-2 cohort who completed FFQs, those who were strict vegetarians had a similar amount of total protein intake compared those who were semi-, pesco-, lactoovo, and non-vegetarians. 70Additionally, strict vegetarians who were consumers of the highest amount of plant-based foods exceeded their minimum requirements for dietary protein intake.Similarly, data from the European Prospective Investigation into Cancer and Nutrition-Oxford study have shown that participants who consumed plant-based diets averaged ~13% of energy intake from protein, exceeding the minimum recommendations from United Kingdom and United States guidelines. 71,72ven strong evidence supporting the role of low-protein diets in delaying CKD progression, experts in the field have proposed a patient-centered, pragmatic plant-dominant low-protein diet (PLADO) comprised of 1) dietary protein intake of 0.6 to 0.8 g/kg/day from 50% plant-based sources, 2) higher fiber intake of >25 g/day, 3) low-sodium intake of <4 g/day (<3 g/day if edema or hypertension are present), and 4) adequate caloric intake of 30 to 35 kcal/kg/day administered by dietitians trained in NDD-CKD care. 57,73,74There are currently ongoing studies and trials evaluating the efficacy and safety of the PLADO diet in patients with NDD-CKD, as well as its counterpart in diabetic kidney disease (known as the plant-focused low-protein diet for chronic kidney disease in diabetes "PLAFOND" diet) (Table 3). 75,76Mixed methods research has also investigated the potential challenges as well as approaches to optimize successful implementation of plant-based diets by kidney dietitians and other multidisciplinary team members. 77

Salutary Impact of Plant-Based Diets on Uremic Complications
In addition to delaying or averting the need for renal replacement therapy by decreasing CKD progression, a PLADO diet may have salutary effects on other uremic complications, including reduction of metabolic acidosis, mineral and bone disorders, and uremic toxin generation (Figure 2). 57,73,74

Metabolic Acidosis
Whereas animal-based proteins increase dietary acid load in CKD, plant-based foods are acid-neutral or alkali-producing. 56,78Acid is generated from animal protein intake due to the oxidization of the amino acids methionine and cysteine to inorganic sulfate. 56In contrast, plant-based foods contain citrate and malate as a form of natural dietary alkali, which is then converted to bicarbonate.On average, the Western diet (high in animal protein and low in plant-based protein) generates a dietary acid load of ~1 mEq/kg/day (i.e., 70 mEq/day in a 70-kg person).Decreased net endogenous acid production may in turn lead to decreased endothelin I, aldosterone, and angiotensin II levels and preservation of glomerular filtration rate, as well as prevention of metabolic acidosis leading to decreased bone resorption, insulin resistance, and sarcopenia. 79sed on the premise that acidosis increases kidney angiotensin II, which in turn mediates CKD progression in experimental models, 56,79 well-designed clinical studies have sought to test the hypothesis that fruits and vegetables may be effective in reducing metabolic acidosis, kidney angiotensin II, and eGFR decline. 80,81In a recent clinical trial of stage 3 NDD-CKD and normal plasma total CO 2 levels (22-24 mmol), 108 patients were randomized to usual care versus interventions to reduce dietary acid by 50% using sodium bicarbonate or fruits and vegetables.Participants in the usual care arm experienced a reduction in plasma total CO 2 and increased urinary angiotensinogen (i.e., proxy of kidney angiotensin II) levels, whereas those in the bicarbonate or fruits and vegetables arm experienced higher total CO 2 and decreased urinary angiotensinogen levels over time. 81Although creatinine-and cystatin C-based eGFR levels decreased in both arms, there was lesser decline in the intervention versus usual care arm after 3 years of follow-up.Another clinical trial of 71 patients with stage 4 NDD-CKD due to hypertension with low plasma total CO 2 levels (<22 mmol) randomized participants to daily oral sodium bicarbonate therapy versus fruits and vegetables dosed to reduce dietary acid by 50% over 1 year.Participants in the fruits and vegetables arm achieved higher plasma total CO 2 levels consistent with improved metabolic acidosis, as compared with the sodium bicarbonate arm; both groups experienced improved urine indices of kidney injury without increases in plasma potassium levels after 1 year. 80hese data suggest that a diet emphasizing fruits and vegetables may be a preferable alternative (and perhaps more palatable option without added sodium load) than alkali supplements as a means to treat metabolic acidosis. 78

Mineral and Bone Disorders
3][84] While inorganic sources (e.g., food additives) more predominantly contribute to hyperphosphatemia due to their high bioaccessibility (i.e., as high as 100%), organic sources such as dietary protein are also a key contributor to the dietary phosphate load.Notably, phosphorus from animal proteins (which occurs in the form of caseins for dairy products) have a higher bioaccessibility (40%-60%) than phosphorus from plant-based proteins (which are often found in phytates) which have a lower bioaccessibility of 20% to 40% due to the inability of the small intestine to degrade phytate as it does not express phytase. 85In a report of data from NHANES, Moore et al. demonstrated that the inorganic phosphates added to the food supply are associated with small but significant increases in serum phosphorus even when controlling for levels of kidney function. 86inical studies have also corroborated that plant versus animal protein sources influence phosphorus homeostasis in CKD.In a crossover trial of nine patients with NDD-CKD who underwent 7 days of a vegetarian diet and 7 days of a meat diet with equivalent nutrients, receipt of the vegetarian diet led to lower serum phosphorus and fibroblast growth factor-23 levels, as well as decreased phosphaturia as compared with the meat diet. 87Recognizing the limitations of traditional methods of assessing dietary phosphate load, kidney nutrition investigators have developed a novel "Phosphatemic Index" to evaluate phosphate load based on its bioavailability. 88Recently, 20 healthy adults were administrated ten different test foods each containing 200 mg of phosphorus in order to assess their Phosphatemic Index.The Phosphatemic Index was calculated from the area under the curve of time versus serum phosphorus concentration curves.The study demonstrated that foods from animal sources (e.g., milk/dairy, pork/ham, etc.) tended to have higher Phosphatemic Index values versus foods from plant-based sources (e.g., soy/tofu).Subsequent ingestion of high Phosphatemic Index test meals led to higher serum fibroblast growth factor-23 levels and lower activated vitamin D levels compared with ingestion of lower Phosphatemic Index test meals. 88

Uremic Toxin Generation
Growing data also show that a plant-dominant diet reduces the generation of uremic toxins, likely due to a greater content of fiber. 57,73,74Dietary fiber, a nondigestible form of carbohydrate found in plant-based foods such as fruits, vegetables, whole grains, legumes, pulses, nuts, and seeds, and has been associated with a number of other health benefits, including improvement in blood pressure, glycemic control, dyslipidemia, weight modulation, constipation, and intestinal microbiota composition and function. 89Moreover, fiber intake correlates with a decrease in the inflammatory state, delays the progression of renal disease, and reduces overall mortality in nephropathic patients. 90,91In addition to a plant-dominant, fiber-rich diet leading to a reduction in gut bacteria-derived toxins such as trimethylamine N-oxide (i.e., a risk factor for insulin resistance and cardiovascular disease), greater intake of fiber may increase the generation of favorable short-chain fatty acids that may improve insulin sensitivity and reduce systemic inflammation. 92In a study of 15 vegetarians and 11 individuals who consumed an unrestricted diet with normal kidney function and underwent measurement of the urinary excretion of two solutes generated by colon bacteremia and found in uremia, namely p-cresol sulfate (PCS) and indoxyl sulfate (IS), both PCS and IS excretion were observed to be lower in vegetarians. 93Additionally, among vegetarians, lower excretion of PCS and IS were observed with higher fiber and lower protein intake.In a clinical trial of 56 maintenance hemodialysis patients who were randomized to daily supplements containing resistance starch (i.e., a form of dietary fiber) versus control starch for 6 weeks, those in the resistance starch arm experienced significant reductions in unbound/free IS and PCS levels and total IS levels, although the reduction in total PCS levels were not significant as compared with the control arm. 94

Practical Implementation of Dietary Interventions
9][50] Both the ISRNM and KDOQI recommendations underscore the essential role that kidney dietitians play in individualized medical nutritional therapy, as well as routine nutritional assessments. 23,28 patient-centered approach involves a shared understanding of treatment goals, effective communication to alleviate anxieties around food or food misconceptions, individualized advice, and assistance with implementation of dietetic advice in the face of a large symptom burden.In addition, attention to the dietary pattern rather than individual foods is important, and consideration given to the important cultural and social roles of food.Recognizing that some geographic catchments (i.e., developing countries) and/or health-care systems may have limited availability of and/or inadequate infrastructure to support the involvement of kidney dietitians, expanded use of telehealth and telemedicine services may be options to circumvent these barriers in access. 28Additionally, the ISRNM and other organizations such as the National Kidney Foundation and Academy of Nutrition and Dietetics have pioneered various in-person and tele-learning platforms to support the training of dietitians and other clinicians in kidney nutrition. 95,96veral innovative clinical models and studies have shown that providing patients with more personalized options ("multiple choice system") and flexibility promotes adherence, dietary satisfaction, and quality of life.In a feasibility study of 131 patients with advanced CKD who were offered three dietary options, namely normalization of protein intake (0.8 g/kg/day), moderate protein restriction (0.6 g/kg/day) with a traditional mixed protein diet, or moderate protein restriction with a plant-based diet supplemented with keto acids, using an individualized stepwise approach, protein restriction was found to be feasible and was associated with stable nutritional status in a population largely of elderly age and high comorbidity burden. 51In another study of patients with severe or rapidly progressive NDD-CKD who were offered three LPD options (i.e., vegan diets supplemented with alpha-keto acids and essential amino acids; protein-free food in substitution of normal bread and pasta; or other diet, such as traditional, vegan nonsupplemented and tailored), excellent adherence was observed across all LPD arms without observed differences in mortality or timing of dialysis initiation. 66other key consideration in the practical implementation of these dietary interventions is their pairing with evidence-based pharmacotherapies.As one example, while the traditional paradigm has been to restrict dietary potassium intake in moderate-to-advanced CKD given concerns about the ill effects of hyperkalemia, there is lack of evidence to support the benefits of this practice, 89,97 and limited observational data have shown weak associations between dietary potassium intake and serum potassium levels. 98Furthermore, restricting heart-healthy fruits and vegetables and dietary patterns with a greater potassium content (i.e., DASH, PLADO/plant-focused low-protein diet for chronic kidney disease in diabetes diets) could potentially have negative effects on the cardiovascular health and survival of patients with CKD. 57,89,97In a retrospective analysis of 3,172 NHANES participants with kidney dysfunction who underwent dietary potassium and fiber intake assessment by 24-hour dietary recall, those who had concomitant low potassium and fiber intake had higher death risk versus those with high potassium and fiber consumption. 89Similarly, in a multicenter prospective observational study of 415 hemodialysis patients who underwent protocolized FFQs, lower dietary potassium intake was associated with worse survival. 97ence, the utilization of novel potassium binders (if available) may allow for liberalization of dietary potassium intake to support greater consumption of PLADO diets, as well as continuing reno-protective renin-angiotensin-aldosterone inhibitors and nonselective steroidal mineralocorticoid receptor antagonists and avoiding/delaying the need for renal replacement therapy.Additionally, low-protein diets may have synergistic effects when used in conjunction with renin-angiotensin-aldosterone inhibitor and novel sodium-glucose cotransporter-2 inhibitors in attenuating proteinuria and CKD progression. 99

Conclusion
In summary, while dialysis has been the dominant treatment paradigm in patients with advanced kidney disease who are ineligible for or unlikely to receive kidney transplantation, growing interest in conservative and preservative care of NDD-CKD has emerged and dietary interventions are central to management.While solid evidence supports the use of low-protein diets in ameliorating CKD progression, further research including clinical trials and rigorous longitudinal observational studies are needed to determine the impact of PLADOs on kidney health outcomes and patient-centered endpoints, including HRQOL, functional status, and symptom burden.Furthermore, using an individualized approach that incorporates multidisciplinary collaboration with specialty-trained kidney dietitians can enhance the effectiveness, safety, and adherence to dietary interventions in the conservative and preservative care of CKD.Finally, an optimal approach in the nutritional management of CKD should emphasize shared decision-making with patients and their care partners, education and counseling regarding evidence-based dietary approaches, personalized nutritional advice, and effective communication and discussion of shared goals that includes consideration of patient-centered outcomes, including HRQOL and alleviation of symptom burden.

Practical Application
Diet plays an important role in the conservative management and preservation of kidney function.Guidelines recommend low-protein diets to reduce the progression of kidney disease.There is also increasing research showing that plant-based low-protein diets may benefit kidney health.Multifaceted approach in the conservative and preservative management of kidney disease.Benefits of a PLADO in the conservative and preservative management of CKD.CKD, chronic kidney disease.
.R. reports receiving honoraria from AstraZeneca, Fresenius, and Vifor.B.M.K. reports receiving research funding from the Academy of Nutrition and Dietetics Foundation, National Kidney Foundation, and has served as a scientific consultant or member of the Academy of Nutrition and Dietetics, International Society of Renal Nutrition and Metabolism, Journal of Renal Nutrition, Fresenius Medical Care, and Abbott Nutrition Health Institute.A.B. is part of the next-generation scientist cohort of the National Dairy Council.C.P.K. reports receiving honoraria from Abbott, Abbvie, Akebia, AstraZeneca, Bayer, Boehringer Ingelheim, Cara Therapeutics, CSL Vifor, GSK, Pharmacosmos, ProKidney, and Takeda.G.B.P reports receiving honoraria from Fresenius Kabi, Doctor Shar, and Baxter.
Comparison of the Traditional Diabetes and Kidney Diets to PLADO and PLAFOND Diets 57,76,100,101 Standard ADA Diet Traditional (Nondialysis) Kidney Diet PLADO and PLAFOND diets Proportion of plant-based protein Diabetes Association; PLADO, plant-dominant low-protein diet; PLAFOND, plant-focused low-protein diet for chronic kidney disease in diabetes.* Lower sodium target of <3 g/d if edema or uncontrolled hypertension present.J Ren Nutr.Author manuscript; available in PMC 2024 February 16.