Case Reports and Series
Chondroid Syringoma of the Foot: A Rare Diagnosis

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Abstract

Chondroid syringoma is a rare tumor with the potential for malignant transformation and distant metastasis. The site of predilection for benign chondroid syringoma is the head and neck region, and it is less likely to involve the foot. In contrast, malignant chondroid syringoma is more commonly encountered in the extremities and is characterized by rapid growth, local invasion, and distant metastasis. We report an unusual case of benign chondroid syringoma in a 47-year-old female who presented with a 20-year history of a mass in her left foot to bring such cases to the attention of foot and ankle specialists. We highlight the histologic diagnosis and surgical procedures with a 6-month postoperative follow-up period. It is unlikely that a treating physician would anticipate this histologic tumor type, considering the rarity of the condition, the long history of this patient's lesion, and the benign presentation in the extremities.

Section snippets

Case Report

A 47-year-old female presented in July 2012 with a solitary slow-growing painless mass on the plantar aspect of her left foot. The patient reported having had the lesion for approximately 20 years; however, she had noted a relatively more rapid increase in the size of the lesion in the previous 2 years. The patient reported no significant medical or surgical history, no allergies, no medication use, and no family history of malignancy. She denied any paresthesia or motor weakness in the left

Discussion

The diagnosis of adnexal neoplasms presents difficulties related to the large variety of tumors and their variant forms and the frequency of differentiation along ≥2 adnexal lines in the same tumor 17, 21. CS is a benign appendageal tumor with eccrine differentiation 17, 21. Benign CSs, however, including those with a long-standing asymptomatic clinical course, are known to have the potential for rapid malignant transformation 3, 17. Malignant CS is more commonly encountered in the extremities

Acknowledgments

The authors would like to thank Laura Gabbe, MS, from the Clinical Research Department at Lutheran Medical Center, Brooklyn, NY, for her invaluable assistance with writing and editing this paper.

References (29)

  • G. Villalón et al.

    Chondroid syringoma: a clinical and histological review of eight cases

    Actas Dermosifiliogr

    (2006)
  • J.C. Steinmetz et al.

    Malignant chondroid syringoma with widespread metastasis

    J Am Acad Dermatol

    (1990)
  • L.E. Zimmerman et al.

    Histological Typing of Tumour of the Eye and Its Adnexa. International Histological Classification of Tumour, No. 24

    (1980)
  • A. Agrawal et al.

    Chondroid syringoma

    Singapore Med J

    (2008)
  • P. Hirsch et al.

    Chondroid syringoma: mixed tumor of skin, salivary gland type

    Arch Dermatol

    (1961)
  • R. Yavuzer et al.

    Chondroid syringoma: a diagnosis more frequent than expected

    Dermatol Surg

    (2003)
  • M. Bekerecioglu et al.

    Benign chondroid syringoma: a confusing clinical diagnosis

    Eur J Plast Surg

    (2002)
  • D. Hardisson et al.

    Giant chondroid syringoma of the axilla

    J Cutan Med Surg

    (1998)
  • K. Sliwa-Hähnle et al.

    Chondroid syringoma of the abdominal wall: a case report and review of the literature

    S Afr J Surg

    (1996)
  • T. Kitazawa et al.

    Chondroid syringoma of the orbit

    Ann Plast Surg

    (1999)
  • J.W. Poku et al.

    Chondroid syringoma of the scrotum

    J Int Med Res

    (1996)
  • K. Nemoto et al.

    Chondroid syringoma of the hand

    Scand J Plast Reconstr Surg Hand Surg

    (2002)
  • M.D. Barnett et al.

    Recurrent malignant chondroid syringoma of the foot: a case report and review of the literature

    Am J Clin Oncol

    (2000)
  • S. Hakan et al.

    Benign chondroid syringoma: atypical presentation of a rare eccrine tumor

    J Foot Ankle Surg

    (2011)

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