Original Investigations: Dialysis TherapiesSerum markers of periodontal disease status and inflammation in hemodialysis patients*,**,★
Section snippets
Subjects
The study was approved by the Beth Israel Medical Center Institutional Review Board, and all subjects included on the study signed informed consent forms. Subjects were recruited from an adult outpatient dialysis unit of Beth Israel Medical Center (New York, NY). All subjects underwent dialysis three times weekly using high-flux polysulfone dialyzers and ultrapure water. Average single-pool Kt/V for the unit was 1.55. Edentulous patients were not included on the study.
Study design
Patient demographics,
Demographic characteristics of the HD subject population
Mean age of subjects was 53.3 ± 16.1 years, with a median time on dialysis therapy of 22 months (range, 0 to 148 months). Forty-six subjects (54%) were men; 27 subjects (31%) reported their race as black; 30 subjects (35%), as white; and 29 subjects (34%), as other. Thirty-three subjects (38%) had diabetes; the majority (28 of 33 subjects; 85%) had type 2 diabetes. Ten subjects (12%) were current smokers, 8 subjects (9%) were former smokers, 39 subjects (45%) denied ever smoking, and smoking
Discussion
The primary objective of this study is to determine whether destructive periodontal diseases contribute to increased systemic inflammation, reflected by CRP values, in patients with ESRD on maintenance HD therapy. Elevated CRP level is known to be a robust risk factor for both cardiovascular and all-cause mortality in this population.2 IgG antibody level to P gingivalis was used as a serum marker of destructive periodontal disease because previous studies of the general adult population
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Supported in part by award no. DE 10593 from The National Institutes of Health.
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Address reprint requests to Margaret A. Rahmati, MB, MRCP, 2 City Heights, 82 Old Snow Hill, Birmingham, West Midlands, B4 6HW, UK. E-mail: [email protected]
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