Liver damage in the rat induces hepatocyte stem cells from biliary epithelial cells
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The role of stem cells in the hepatobiliary system and in cancer development: A surgeon’s perspective
2018, Stem Cells and Cancer in Hepatology: From the Essentials to ApplicationHepatic Progenitor Cells: An Update
2017, Gastroenterology Clinics of North AmericaCitation Excerpt :2-Acetylaminofluorene is used to induce a complete blockage of the proliferative capacity of hepatocytes after a partial HPx. Making use of this rat model in practice, several studies implied a differentiation of oval cells toward hepatocytes.47–52 Additionally, an attractive zebrafish model of Choi and colleagues53 revealed the regenerative capacity of BECs toward hepatocytes after depletion of the hepatocytes due to usage of metronidazole, causing severe liver damage.
Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes
2014, Cell Stem CellCitation Excerpt :Notably, the transcription factor Zeb1, a master regulator epithelial-to-mesenchymal transition (EMT) (Kalluri and Weinberg, 2009), was overexpressed in hepPDs compared with bilPDs (3.6-fold, q < 9 × 10−36) and hepatocytes (3.3-fold, q < 2 × 10−8). Additional genes in this group associated with EMT included Vim (Alison et al., 1996; Demetris et al., 1996), Mst1r, Fzd10, and c-Kit (Chen et al., 2012; Fujio et al., 1994; Yovchev et al., 2008; Wang et al., 2003). Hepatocyte-derived ducts also showed enrichment of genes expressed in neuronal progenitors that were previously identified in human ductular reactions or experimentally induced oval cells, including Nes (Gleiberman et al., 2005), neuronal-cadherin (also called Cdh2) (Mosnier et al., 2009), and Ncam1 (Roskams et al., 1990; Shin et al., 2011; Zhou et al., 2007).
Adult Liver Stem Cells
2013, Handbook of Stem CellsAlternative Cells for Regeneration
2012, Developmental CellCitation Excerpt :In this process, the new hepatocytes are formed by division of existing ones. But if the animals have been treated with a drug to suppress division of hepatocytes, then regeneration still takes place, but now the new hepatocytes arise from oval cells, which are small cells lying in the periportal regions that somewhat resemble embryonic hepatoblasts (Alison et al., 1996). What these phenomena may have in common is that the fibroblasts of the fish fin and the oval cells of the liver are both types of stem cell, capable of reproducing themselves and of generating differentiated progeny.
Adult Liver Stem Cells
2012, Handbook of Stem Cells, Second Edition: Volume 1-2