Linoleic acid-stimulated vascular adhesion molecule-1 expression in endothelial cells depends on nuclear factor-[kappa ]B activation☆
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Influence of omega-3 fatty acids and monounsaturated fats in liver diseases
2020, Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver DiseasesPerturbation of metabolic pathways mediates the association of air pollutants with asthma and cardiovascular diseases
2018, Environment InternationalCitation Excerpt :Few studies associated linoleate with CCVD, although in general ω−6 fatty acids have long been believed to have pro-inflammatory effects in the cardiovascular system. An early in vitro study suggested that linoleate may lead to atherogenesis by NFκB signaling mediated vascular adhesion molecule-1 (VCAM-1) expression (Dichtl et al., 2002). Glycosphingolipid metabolism was found as MITM pathway linking exposure to UFP and CCVD and annotation of sphingosine was confirmed as one of the modulated metabolites in this pathway.
Excessive dietary linoleic acid induces proinflammatory markers in rats
2015, Journal of Nutritional BiochemistryCitation Excerpt :Concomitantly, we found that an excess of dietary LA induced NF-κB translocation in the arterial wall. These results reinforce previous data showing that LA induces NF-κB pathway to up-regulate CAM expressions in vitro [7,46–48] as well as in vivo [49]. Epidemiologic studies also report the presence of IL-1β and TNF-α cytokines in human atherosclerosis lesions [27,33] as well as high plasma concentrations of sVCAM-1 and sICAM-1 in coronary artery disease [50], but the link with dietary LA remains controversial [16].
Pyruvate dehydrogenase kinase 4 (PDK4) could be involved in a regulatory role in apoptosis and a link between apoptosis and insulin resistance
2015, Experimental and Molecular PathologyCitation Excerpt :In these experiments, HeLa cells and HepG2 cells were treated with agents that are known to induce apoptosis and these cells were then assessed for cell death, apoptosis and levels of hPDK4 mRNA. TNFα, ceramide and linoleic acid are known to induce apoptosis (Dichtl et al., 2002; Kim et al., 2005; Lee et al., 2005). To establish the optimal concentration and time course at which these factors induce cell death, HeLa cells and HepG2 cells were treated with different concentrations of TNFα, C2-ceramide, and linoleic acid over a specified time period.
Effects of fatty acids on endothelial cells: Inflammation and monocyte adhesion
2012, Journal of Surgical Research
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Supported by grants from the Swedish Medical Research Council (8311 and 8691), the Swedish Heart-Lung Foundation, the Marianne and Marcus Wallenberg Foundation, the King Gustaf V 80th Birthday Foundation, the Petrus and Augusta Hedlund Foundation, the Foundation For Old Servants, the Professor Nanna Svartz Foundation, and the King Gustaf V and Queen Victoria Foundation. P.E. is supported by a postdoctoral research fellowship from the Swedish Medical Research Council and C.M.G. supported by Grant No. HL18645 from the National Institutes of Health.