Malignant lesions of the ovary in childhood
Section snippets
Germ cell tumors
Germ cell tumors account for 75% to 80% of all neoplastic ovarian masses in most studies.1 The tumors are divided into five subgroups based on the degree of differentiation and the cellular components involved. Dysgerminomas are the least differentiated tumors and are comparable to the seminoma in males. Germ cells that undergo some degree of differentiation before becoming neoplastic yield the embryonic tumors (embryonal carcinoma or teratoma) or the extraembryonic tumors (endodermal sinus
Sex cord stromal tumors
The sex-cord tumors, granulosa cell tumors and Sertoli—Leydig cell tumors arise from stromal components of the ovary and frequently produce hormones that may result in clinically apparent changes in the patient. Granulosa cell tumors account for 1% to 10% of ovarian malignancies in girls under age 20.23, 24, 25 Ninety-five percent of granulosa cell tumors develop in postpubertal women; however, in 80% of the tumors that develop in patients under the age of 20, the tumors exhibit different
Epithelial tumors
Less than 20% of ovarian tumors in childhood are derived from the surface epithelium of the ovary and such tumors are extremely rare before menarche.32, 33 By contrast, in adults, epithelial neoplasms represent the majority of ovarian tumors.34 Although there are numerous classes of epithelial ovarian cancer in adults, the histologic subtypes of epithelial ovarian tumors in children include only serous and mucinous tumors.35 Each of these tumor types may be further characterized as benign,
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Cited by (97)
Ovarian tumors in the pediatric population: An update
2024, Disease-a-MonthControlled aspiration of large paediatric ovarian cystic tumours
2022, Journal of Pediatric SurgeryCitation Excerpt :Apart from the girl with the ruptured malignant adenocarcinoma all other patients are well without evidence of recurrence or fresh metachronous tumours. Ovarian cysts are often simple physiological cysts but up to 50% will be neoplastic tumours [1,2]. In our series, if the ultrasound suggested a complex cyst, an MRI was carried out and reviewed in our MDT.
Analysis of solid ovarian tumours in a Spanish paediatric population
2020, Anales de PediatriaUnderstanding the Value of Tumor Markers in Pediatric Ovarian Neoplasms
2020, Journal of Pediatric SurgeryA Preoperative Scoring System for Adnexal Mass in Children and Adolescents to Preserve Their Future Fertility
2019, Journal of Pediatric and Adolescent Gynecology