Original articles
Predictors of atrial fibrillation after off-pump coronary artery bypass graft surgery

https://doi.org/10.1053/j.jvca.2004.08.005Get rights and content

Abstract

Objective: Atrial fibrillation is the most common complication after coronary artery bypass graft surgery. This arrhythmia may lead to hemodynamic compromise, prolonged hospitalization, and increased risk for cerebral thromboembolism. Older age is the only variable consistently associated with the development of postoperative atrial fibrillation; however, no strong predictive model exists. The purpose of this study was to identify perioperative characteristics associated with new-onset atrial fibrillation in patients undergoing off-pump coronary artery bypass grafting.

Design: Prospective, observational.

Setting: University tertiary care hospital.

Participants: One hundred sixty consecutive patients undergoing off-pump coronary artery bypass grafting.

Interventions: None.

Measurements and Main Results: Incidence of postoperative atrial fibrillation was the major outcome. Atrial fibrillation occurred in 33 patients (20.6%). Multivariate analysis identified reintervention (odds ratio 26.8), revascularization of the ramus medianus (odds ratio 3.9), and age (odds ratio 1.069 per year) as the only independent predictors of postoperative atrial fibrillation. All patients were in sinus rhythm at hospital discharge. One hospital death was noted.

Conclusions: Despite the less invasive approach, the incidence of postoperative atrial fibrillation is high after off-pump coronary artery bypass grafting. Older age, grafting of the ramus medianus, and a redo operation were predictors of new-onset postoperative atrial fibrillation. It is possible that left atrial stretching with heart dislocation during revascularization of the lateral wall could lead to postoperative atrial fibrillation.

Section snippets

Methods

This was a prospective study enrolling 160 patients undergoing elective CABG with the off-pump technique at IRCCS San Raffaele Hospital of Milan. Patients were not included in other trials and represented 47% of all CABG performed at the institution during the study period. After institutional review board approval, data were prospectively obtained for an 8-month period (May 2001-January 2002). Individual informed consent was obtained from all participants. All subjects were >18 years old,

Results

AF occurred in 33 patients, representing 20.6% of the overall population. There was 1 hospital death from acute right ventricular failure. Demographic data and perioperative characteristics were compared for the patients who developed postoperative AF and for those who remained in sinus rhythm (Table 1) with the appropriate univariate p values; age (p = 0.01), redo surgery (p = 0.006), preoperative Ca channel blockers (p = 0.05), intraoperative use of nitrates (p = 0.04), and postoperative

Discussion

This study confirms that the incidence of postoperative AF after CABG is still high even when a beating-heart technique is used,5, 6, 7, 8 occurring in 20.6% of the patients. These data are in accordance to previous reports.1, 3, 9 AF is predicted by age, revascularization of the ramus medianus, and reoperation. The originality of this study is due to the fact that the authors included in the data collection many anesthetic variables (that showed no correlation with the outcome of interest) and

Acknowledgements

The authors thank Gigliola Antonioli, RN, Isabella Ronco, RN, and Monica Lischio, RN, for their collaboration.

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