Original ResearchFull Report: Clinical—PancreasDevelopment and Validation of a Chronic Pancreatitis Prognosis Score in 2 Independent Cohorts
Section snippets
Aims and Study Design
This study was designed according to the Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis statement (TRIPOD).16 In the first phase, we conducted a prospective single-center cohort study on 91 patients (development cohort) with preexisting chronic pancreatitis to develop a severity scoring system in chronic pancreatitis, by using readily available routine laboratory parameters, BMI, imaging, and standardized assessment of pain symptoms. In the
Baseline Parameters Development Cohort
Between January 2011 and January 2013, 91 patients with unequivocal evidence of chronic pancreatitis were prospectively included. Four of these cases were recruited from the outpatient clinic, all others were hospitalized at the time of inclusion. The median age was 55 (range, 25–88 years), 20 cases (22.0%) were women and 71 cases (78%) were men. Suspected etiology of pancreatitis was alcoholic (67.0%), obstructive (2.2%), hereditary (3.3%), and autoimmune (1.1%); the remaining cases were
Discussion
The worldwide incidence of chronic pancreatitis is reported to be between 1.6 and 23 per 100, 000, with an increasing prevalence.21 Although most patients with chronic pancreatitis are treated as outpatients, in 2008 there were 10. 267 (International Classification of Diseases, 10th Revision: K86) hospital admissions for chronic pancreatitis in Germany alone (Federal Statistics Office). This does not include those patients who were coded as having acute pancreatitis, including those due to an
Conclusion
In a type 3 study regarding the TRIPOD reporting criteria, we developed a multivariate prediction model to foresee the individual short-term (12-month) prognosis of patients suffering from chronic pancreatitis by using C-reactive protein, platelet count, HbA1c, BMI, and pain.
References (38)
- et al.
Pain severity reduces life quality in chronic pancreatitis: implications for design of future outcome trials
Pancreatology
(2014) - et al.
Revised classification of pancreatitis. Report of the Second International Symposium on the Classification of Pancreatitis in Marseille, France, March 28-30, 1984
Gastroenterology
(1985) - et al.
Opioid treatment and hypoalbuminemia are associated with increased hospitalisation rates in chronic pancreatitis outpatients
Pancreatology
(2016) - et al.
Diagnosis and grading of chronic pancreatitis by morphological criteria derived by ultrasound and pancreatography
Clin Radiol
(1988) - et al.
Predictive factors for and incidence of hospital readmissions of patients with acute and chronic pancreatitis
Pancreatology
(2015) - et al.
Chronic pancreatitis: an international draft consensus proposal for a new mechanistic definition
Pancreatology
(2016) - et al.
Relationship between pancreatic exocrine function and ductal morphology in chronic pancreatitis
Gastroenterology
(1982) - et al.
Clinical, emotional and social factors associated with quality of life in chronic pancreatitis
Pancreatology
(2010) - et al.
Chronic pancreatitis pain pattern and severity are independent of abdominal imaging findings
Clin Gastroenterol Hepatol
(2015) - et al.
Evolution and regression of pancreatic calcification in chronic pancreatitis. A prospective long-term study of 107 patients
Gastroenterology
(1988)
English language version of the S3-consensus guidelines on chronic pancreatitis: definition, aetiology, diagnostic examinations, medical, endoscopic and surgical management of chronic pancreatitis
Z Für Gastroenterol
Symposium on the etiology and pathological anatomy of chronic pancreatitis: Marseilles, 1963
Am J Dig Dis
The pancreatitis classification of Marseilles-Rome 1988
Scand J Gastroenterol
Classification of pancreatitis
Gut
Pancreatography in chronic pancreatitis: international definitions
Gut
Classification and diagnosis of chronic pancreatitis
J Gastroenterol
A clinically based classification system for alcoholic chronic pancreatitis: summary of an international workshop on chronic pancreatitis
Pancreas
Proposal for a new grading system for chronic pancreatitis: the ABC system
J Clin Gastroenterol
Evaluation of the Manchester classification system for chronic pancreatitis
JOP
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External validation of Chronic Pancreatitis Prognosis Score (COPPS): A prospective cohort study
2022, Digestive and Liver DiseaseCitation Excerpt :Their Socioeconomic status(SES) was assessed by our country specific Kuppuswamy socioeconomic scale, a composite of educational achievement, occupation and income, with updated criteria of income range for the year 2012 [17]. Moreover, at baseline, their pain severity, as worst pain on a Numeric Rating Scale, NRS, (0–10; 0 = no pain; 10 = worst imaginable pain) within the past 7 days, was recorded [13]. Their Body-mass index[BMI= Weight (kg)/ Height[2] (m)] was calculated, functional status(Karnofsky Score [18]) was assessed, and basic laboratory tests including complete blood count, C-reactive protein[CRP] levels and glycated hemoglobin A1c(HbA1c) levels were also obtained at baseline.
Chronic pancreatitis
2020, The LancetManagement of chronic pancreatitis: recent advances and future prospects
2024, Therapeutic Advances in Gastroenterology
Conflicts of interest The authors disclose no conflicts.
Funding This work was supported by the Deutsche Krebshilfe/Dr. Mildred-Scheel-Stiftung (109102), the Deutsche Forschungsgemeinschaft (DFG 1947/A3, MA 4115/1-2/3), the European Union (EU-FP-7: EPC-TM), BMBF FKZ: 01EK1511A, and Landesexzellenzinitiative MV – PePPP.
Author names in bold designate shared co-first authorship
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Authors share co-first authorship
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Authors share co-senior authorship.