Gastroenterology

Gastroenterology

Volume 148, Issue 4, April 2015, Pages 849-850
Gastroenterology

Selected Summary
Homeostatic Restoration of Desmoplastic Stroma Rather Than Its Ablation Slows Pancreatic Cancer Progression

https://doi.org/10.1053/j.gastro.2015.02.043Get rights and content

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Using detailed methods, transcriptome analyses, and orthotopic and genetically engineered mouse models, Sherman et al elegantly show that modulation, rather than ablation, of the desmoplastic stroma, in which PSC regain a more physiologic secretome, offers an attractive therapeutic strategy in pancreatic cancer. The imbalance of desmoplastic stroma driving aggressive tumor behavior has been demonstrated recently (J Pathol 2013;230:107–117). This approach, of reprogramming the pancreatic tumor

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