Effect of morphine on gastroesophageal reflux and transient lower esophageal sphincter relaxation
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Pharmacologic causes of dysphagia
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2017, Clinical Gastroenterology and HepatologyCitation Excerpt :Mu opioids may be associated with dysphagia or heartburn that may reflect intrinsic neural or sphincter dysfunction. In patients with gastroesophageal reflux disease,37 acute morphine administration significantly decreases the rate of transient LES relaxations in patients vs controls, resulting in less reflux episodes and a decrease of the time at pH <4. Resting LES pressure is decreased both in health and in achalasia; swallow-induced LES relaxation is also significantly decreased by morphine in the healthy subjects.29
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