Issue 6, 1973
From the journal:

Journal of the Chemical Society, Perkin Transactions 2

Crystal and molecular structures and absolute configuration of triptolide and tripdiolide, two anti-leukaemic diterpenoid triepoxides

Christopher J. Gilmore  and  Robert F. Bryan  

Abstract

The crystal and molecular structures and absolute configuration of the title compounds, have been determined by three-dimensional, single-crystal, X-ray analysis. Crystals of triptolide (Ia) are monoclinic, space group P21, with a= 13·420(1), b= 6·256(1), c= 11·593(1)Å, β= 118·09(1)°, and Z= 2. Crystals of tripdiolide (Ib) have the same space group, a= 13·680(2), b= 6·253(1), c= 11·684(1)Å, β= 119·05(1)°, and Z= 2. The structure of (Ia) was determined by direct methods and refined to R 0·086, by least-squares methods, for 1044 independent reflections measured by counter diffractometry. The structure of (Ib) was found by direct application of the phase angles for (Ia), and refined by least-squares to R 0·082 for 1399 independent reflections.

Each molecule has an 18(4 → 3)abeo-abietane skeleton, and tripdiolide is 2-hydroxytriptolide.

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Article information

DOI
https://doi.org/10.1039/P29730000816
Article type
Paper

J. Chem. Soc., Perkin Trans. 2, 1973, 816-819

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Crystal and molecular structures and absolute configuration of triptolide and tripdiolide, two anti-leukaemic diterpenoid triepoxides

C. J. Gilmore and R. F. Bryan, J. Chem. Soc., Perkin Trans. 2, 1973, 816 DOI: 10.1039/P29730000816

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