Issue 21, 1994

Synthesis of the phosphonate isostere of carbocyclic 5-bromovinyldeoxyuridine monophosphate

Abstract

The nucleotide analogue 5 has been synthesized, via formation of the diol 11, and has been shown to be inactive against HSV in vitro. Resolution of the intermediate diol 11 was effected using a highly stereoselective enzyme-catalysed acetylation.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1994, 3061-3063

Synthesis of the phosphonate isostere of carbocyclic 5-bromovinyldeoxyuridine monophosphate

D. M. Coe, A. Garofalo, S. M. Roberts, R. Storer and A. J. Thorpe, J. Chem. Soc., Perkin Trans. 1, 1994, 3061 DOI: 10.1039/P19940003061

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