Issue 9, 1992

Multiple-column solid-phase glycopeptide synthesis

Abstract

The preparation of the two new building blocks Nα-Fmoc-Ser(Ac3-α-D-GalpNAc)-OPfp 6 and Nα-Fmoc-Thr(Ac3-α-D-GalpNAc)-OPfp 7 and their application in a simultaneous multiple-column solid-phase synthesis of 40 different O-glycopeptides from human intestinal mucin and porcine submaxillary gland mucin are described. All glycopeptides were obtained in excellent purity and were characterised by 1D- and 2D-1H NMR spectroscopy and amino acid analyses.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1992, 1163-1171

Multiple-column solid-phase glycopeptide synthesis

S. Peters, T. Bielfeldt, M. Meldal, K. Bock and H. Paulsen, J. Chem. Soc., Perkin Trans. 1, 1992, 1163 DOI: 10.1039/P19920001163

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