Issue 7, 1988
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Synthesis of indolin-2-ones (oxindoles) related to mitomycin A

Ralph A. Raphael  and  Paul Ravenscroft  

Abstract

Oxindoles (Indolin-2-ones) containing the functionality of the first two rings of the mitomycin A structure have been synthesized. Attempts to employ the oxindole grouping to construct the third ring were unsuccessful because of the resistance of the oxindole group or its derivatives towards nucleophilic attack. An unusual methylation of 3-methyl-5-nitrobenzene-1,2,4-triol to give the (E)-3,6-dihydroxy-2-methyl-1,4-benzoquinone 4-methoxyimine N-oxide is noted. A novel indole formation is described.

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Article information

DOI
https://doi.org/10.1039/P19880001823
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1988, 1823-1828

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Synthesis of indolin-2-ones (oxindoles) related to mitomycin A

R. A. Raphael and P. Ravenscroft, J. Chem. Soc., Perkin Trans. 1, 1988, 1823 DOI: 10.1039/P19880001823

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