SCHEDULED MAINTENANCE
Key steps in a total synthesis of (+)-milbemycin β3are the construction of the 1,7-dioxaspiro[5.5]undecane (10) by a Lewis acid-catalysed intramolecular directed aldol reaction and the use of sulphone-based olefination reactions for the construction of the double bonds at C(10)–C(11) and C(14)–C(15)
P. J. Kocieński, S. D. A. Street, C. Yeates and S. F. Campbell, J. Chem. Soc., Perkin Trans. 1, 1987, 2171 DOI: 10.1039/P19870002171
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