Issue 0, 1981
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

The preparation of some specifically tritium labelled carcinogenic hydrocarbons and their covalent binding to DNA

G. Michael Blackburn,   Andrew J. Flavell,   Lawrence Orgee,   James P. Will  and  Gillian M. Williams  

Abstract

Syntheses are described for the preparation of [9(10)-3H]anthracene, [6-3H]benzo[a]pyrene, and [7-Me-3H1]-7,12-dimethylbenz[a]anthracen. The nature and extent of covalent binding of these hydrocarbons to calf thymus DNA resulting from ultraviolet or gamma irradiation, from oxidative processes involving iodine or hydrogen peroxide, or from oxygen in conjunction with NADPH and a rat liver microsomal preparation is investigated. The displacement of tritium on hydrocarbon bonding to DNA identifies position-6 in benzo[a]pyrene and position-9 in anthracene as sites for DNA binding by irradiation processes or by chemical oxidation. Metabolic binding of benzo[a]pyrene to DNA shows an altered regioselectivity while that for 7,12-dimethylbenz[a]anthracene appears to to involve the 7-methyl group.

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/P19810003196
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1981, 3196-3204

Permissions

Request permissions

The preparation of some specifically tritium labelled carcinogenic hydrocarbons and their covalent binding to DNA

G. M. Blackburn, A. J. Flavell, L. Orgee, J. P. Will and G. M. Williams, J. Chem. Soc., Perkin Trans. 1, 1981, 3196 DOI: 10.1039/P19810003196

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements