Issue 0, 1971

Experiments on the synthesis of tetracycline. Part VIII. An attempted total synthesis of 4-hydroxy-6-methylpretetramid

Abstract

The use of a 1,2,4-trimethoxy-ring A component in producing the tetracycline analogue 12-ethylenedioxy-5,5aα,6,11,11aα,12-hexahydro-6β,10-dihydroxy-1,3,4-trimethoxy-6α-methyl-11-oxonaphthacene-2-carbox-amide (XX; R = H) is described. This potential tetracycline precursor is converted into 6-methylpretetramid, which itself has been oxidised to 4-hydroxy-6-methylpretetramid.

Article information

Article type
Paper

J. Chem. Soc. C, 1971, 2225-2231

Experiments on the synthesis of tetracycline. Part VIII. An attempted total synthesis of 4-hydroxy-6-methylpretetramid

D. H. R. Barton, P. D. Magnus and M. J. Pearson, J. Chem. Soc. C, 1971, 2225 DOI: 10.1039/J39710002225

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