Dess–Martin periodinane-mediated oxidation of the primary alcohol of cytidine into a carboxylic acid

Alexandra R. E. Serre; Vibhu Jha; Adèle Rivault; Leif A. Eriksson; Goreti Ribeiro Morais; Robert A. Falconer

doi:10.1039/D4OB00240G

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Dess–Martin periodinane-mediated oxidation of the primary alcohol of cytidine into a carboxylic acid†

Alexandra R. E. Serre,^a Vibhu Jha,‡^b Adèle Rivault,^a Leif A. Eriksson,

^b Goreti Ribeiro Morais^a and Robert A. Falconer

*^a

Author affiliations

* Corresponding authors

^a Institute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UK
E-mail: r.a.falconer1@bradford.ac.uk

^b Department of Chemistry and Molecular Biology, University of Gothenburg, 405 30 Göteborg, Sweden

Abstract

Herein the first example of conversion of alcohols into carboxylic acids by use of the Dess–Martin Periodinane (DMP), which is otherwise routinely employed for the conversion to aldehydes, is reported. This methodology will have significant potential utility in the synthesis of cytidine analogues and other related biologically important molecules.

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Article information

DOI: https://doi.org/10.1039/D4OB00240G
Article type: Communication
Submitted: 14 Feb 2024
Accepted: 16 Apr 2024
First published: 16 Apr 2024
This article is Open Access

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Org. Biomol. Chem., 2024,22, 3848-3853

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Dess–Martin periodinane-mediated oxidation of the primary alcohol of cytidine into a carboxylic acid

A. R. E. Serre, V. Jha, A. Rivault, L. A. Eriksson, G. Ribeiro Morais and R. A. Falconer, Org. Biomol. Chem., 2024, 22, 3848 DOI: 10.1039/D4OB00240G

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Organic & Biomolecular Chemistry

Dess–Martin periodinane-mediated oxidation of the primary alcohol of cytidine into a carboxylic acid†

Abstract

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Article information

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Dess–Martin periodinane-mediated oxidation of the primary alcohol of cytidine into a carboxylic acid

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