Diastereoselective synthesis of functionalized spiroindolines via intramolecular ipso-iodocyclization/nucleophile addition cascade reactions of indole-tethered ynones†
Debojyoti
Bag 
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and
Sanghapal D.
Sawant
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ab
and
Sanghapal D.
Sawant
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Abstract
Herein, we describe a highly diastereoselective approach for synthesizing polyfunctionalized spiroindolines from indolyl-ynones involving an ipso-iodocyclization/nucleophile addition cascade. The developed strategy allows the formation of a spirocyclic core and the installation of two functional groups in a single operation. Also this strategy is accompanied by the generation of two C–C and one C–I bonds and two contiguous stereocenters.
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