Internal standard optimization advances sensitivity and robustness of ratiometric detection method

Yuning Jiang; Jiaying Cao; Sen Hu; Tao Cheng; Hanyu Wang; Xiaoyu Guo; Ye Ying; Xinling Liu; Feng Wang; Ying Wen; Yiping Wu; Haifeng Yang

doi:10.1039/D4AN00266K

Internal standard optimization advances sensitivity and robustness of ratiometric detection method†

Yuning Jiang,^a Jiaying Cao,^a Sen Hu,^a Tao Cheng,^a Hanyu Wang,^a Xiaoyu Guo,^a Ye Ying,^a Xinling Liu,

^a Feng Wang,^a Ying Wen,^a Yiping Wu*^a and Haifeng Yang

*^a

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* Corresponding authors

^a The Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry, Ministry of Education, and Shanghai Key Laboratory of Rare Earth Functional Materials, College of Environmental and Geographic Sciences, Shanghai Normal University, Shanghai 200234, China
E-mail: yipingwu@shnu.edu.cn, hfyang@shnu.edu.cn

Abstract

We design a p-aminothiophenol (pATP) modified Au/ITO chip to determine nitrite ions in lake water by a ratiometric surface-enhanced Raman scattering (SERS) method based on nitrite ions triggering the transformation of pATP to p,p′-dimercaptoazobenzene (DMAB). Intriguingly, by using the SERS peak (at 1008 cm⁻¹) from benzoic ring deforming as an internal standard instead of the traditional peak at 1080 cm⁻¹, the detection sensitivity of the method was improved 10 times.

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Internal standard optimization advances sensitivity and robustness of ratiometric detection method†

Abstract

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