Issue 2, 2024

The application of nanoparticles based on ferroptosis in cancer therapy

Abstract

Ferroptosis is a new form of non-apoptotic programmed cell death. Due to its effectiveness in cancer treatment, there are increasing studies on the application of nanoparticles based on ferroptosis in cancer therapy. In this paper, we present a summary of the latest progress in nanoparticles based on ferroptosis for effective tumor therapy. We also describe the combined treatment of ferroptosis with other therapies, including chemotherapy, radiotherapy, phototherapy, immunotherapy, and gene therapy. This summary of drug delivery systems based on ferroptosis aims to provide a basis and inspire opinions for researchers concentrating on exploring this field. Finally, we present some prospects and challenges for the application of nanotherapies to clinical treatment by promoting ferroptosis in cancer cells.

Graphical abstract: The application of nanoparticles based on ferroptosis in cancer therapy

Article information

Article type
Review Article
Submitted
04 Oct 2023
Accepted
04 Dec 2023
First published
08 Dec 2023

J. Mater. Chem. B, 2024,12, 413-435

The application of nanoparticles based on ferroptosis in cancer therapy

Y. Li, C. Wei, J. Yan, F. Li, B. Chen, Y. Sun, K. Luo, B. He and Y. Liang, J. Mater. Chem. B, 2024, 12, 413 DOI: 10.1039/D3TB02308G

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