Issue 1, 2024, Issue in Progress
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RSC Advances

Asymmetric Michael addition catalysed by copper–amyloid complexes†

Nobutaka Fujieda, ORCID logo *a   Atsushi Tonomura,b   Tomofumi Mochizukic  and  Shinobu Itoh ORCID logo *b  

* Corresponding authors

a Department of Applied Biological Chemistry, Graduate School of Agriculture, Osaka Metropolitan University, 1-1 Gakuen-cho, Naka-ku, Sakai-shi, Osaka 599-8531, Japan
E-mail: fujieda@omu.ac.jp

b Department of Molecular Chemistry, Division of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Osaka 565-0871, Japan

c Department of Agricultural Biology, Graduate School of Agriculture, Osaka Metropolitan University, 1-1 Gakuen-cho, Naka-ku, Sakai-shi, Osaka 599-8531, Japan

Abstract

We developed self-assembled peptides containing a partial amyloid β protein sequence and a metal-coordination site. The amyloid fibril–copper complexes exhibited excellent reactivity and moderate enantioselectivity in Michael addition reactions with 2-azachalcone and dimethylmalonate. The catalytic amyloids were characterized using various measurements to confirm their amyloid-like nanofibre structures.

Graphical abstract: Asymmetric Michael addition catalysed by copper–amyloid complexes

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Article information

DOI
https://doi.org/10.1039/D3RA07900G
Article type
Paper
Submitted
18 Nov 2023
Accepted
12 Dec 2023
First published
02 Jan 2024
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2024,14, 206-210

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Asymmetric Michael addition catalysed by copper–amyloid complexes

N. Fujieda, A. Tonomura, T. Mochizuki and S. Itoh, RSC Adv., 2024, 14, 206 DOI: 10.1039/D3RA07900G

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