Highly regioselective 6-exo-dig iodo/bromo cyclizations of functionalized 5-amino propargyl pyrimidinones: an efficient synthesis of functionalized pteridines

Rayees Ahmad Naikoo; Rupesh Kumar; Rashmi Sharma; Dinesh Mahajan; Gaurav Bhargava

doi:10.1039/D3RA05651A

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Highly regioselective 6-exo-dig iodo/bromo cyclizations of functionalized 5-amino propargyl pyrimidinones: an efficient synthesis of functionalized pteridines†

Rayees Ahmad Naikoo,^a Rupesh Kumar,

^a Rashmi Sharma,*^a Dinesh Mahajan

^b and Gaurav Bhargava

*^a

Author affiliations

* Corresponding authors

^a Department of Chemical Sciences, I. K. Gujral Punjab Technical University, Kapurthala, Punjab 144603, India
E-mail: gaurav@ptu.ac.in, rsharma082@gmail.com

^b Translational Health Science and Technology Institute, Faridabad, Haryana, India

Abstract

The manuscript describes the highly regioselective 6-exo-dig iodo/bromo cyclization of functionalized N-propagyl-amino-pyrimidinones under ambient conditions. The cyclization afforded functionalized pteridines in excellent yields. The optimized procedures are mild, operationally simple and working successfully with different substrates. The synthesis of functionalized pteridines is of great significance because of their potential pharmacological profile.

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Article information

DOI: https://doi.org/10.1039/D3RA05651A
Article type: Paper
Submitted: 19 Aug 2023
Accepted: 20 Oct 2023
First published: 31 Oct 2023
This article is Open Access

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RSC Adv., 2023,13, 31891-31896

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Highly regioselective 6-exo-dig iodo/bromo cyclizations of functionalized 5-amino propargyl pyrimidinones: an efficient synthesis of functionalized pteridines

R. A. Naikoo, R. Kumar, R. Sharma, D. Mahajan and G. Bhargava, RSC Adv., 2023, 13, 31891 DOI: 10.1039/D3RA05651A

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Highly regioselective 6-exo-dig iodo/bromo cyclizations of functionalized 5-amino propargyl pyrimidinones: an efficient synthesis of functionalized pteridines†

Abstract

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Highly regioselective 6-exo-dig iodo/bromo cyclizations of functionalized 5-amino propargyl pyrimidinones: an efficient synthesis of functionalized pteridines

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