Issue 28, 2023, Issue in Progress
From the journal:

RSC Advances

Pd-catalyzed intermolecular consecutive double Heck reaction “on water” under air: facile synthesis of substituted indenes†

Dong Wei, ORCID logo abc   Han-Yu Lu, ORCID logo c   Han-Zhe Miao,c   Chen-Guo Feng, ORCID logo *d   Guo-Qiang Lin*cd  and  Yingbin Liu ORCID logo *ae  

* Corresponding authors

a State Key Laboratory of Systems Medicine for Cancer, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
E-mail: laoniulyb@shsmu.edu.cn

b Shanghai Key Laboratory of Biliary Tract Disease Research, Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

c Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

d The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

e Department of Biliary-Pancreatic Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Abstract

An efficient and environmentally benign method for the preparation of substituted indene derivatives has been developed by using water as the sole solvent. This reaction proceeded under air, tolerated a wide range of functional-groups and was easily scaled up. Bioactive natural products like indriline were synthesized via the developed protocol. Preliminary results demonstrate that the enantioselective variant can also be achieved.

Graphical abstract: Pd-catalyzed intermolecular consecutive double Heck reaction “on water” under air: facile synthesis of substituted indenes

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Article information

DOI
https://doi.org/10.1039/D3RA03510G
Article type
Paper
Submitted
25 May 2023
Accepted
13 Jun 2023
First published
26 Jun 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 19312-19316

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Pd-catalyzed intermolecular consecutive double Heck reaction “on water” under air: facile synthesis of substituted indenes

D. Wei, H. Lu, H. Miao, C. Feng, G. Lin and Y. Liu, RSC Adv., 2023, 13, 19312 DOI: 10.1039/D3RA03510G

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