Issue 16, 2023
From the journal:

RSC Advances

Anticancer therapeutic potential of benzofuran scaffolds

Ashraf A. Abbas ORCID logo a  and  Kamal M. Dawood ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt
E-mail: kmdawood@sci.cu.edu.eg
Fax: +20-2-35727556
Tel: +20-2-35676602

Abstract

Benzofuran moiety is the main component of many biologically active natural and synthetic heterocycles. These heterocycles have unique therapeutic potentials and are involved in various clinical drugs. The reported results confirmed the extraordinary inhibitory potency of such benzofurans against a panel of human cancer cell lines compared with a wide array of reference anticancer drugs. Several publications about the anticancer potencies of benzofuran-based heterocycles were encountered. The recent developments of anticancer activities of both natural and synthetic benzofuran scaffolds during 2019–2022 are thoroughly covered. Many of the described benzofurans are promising candidates for development as anticancer agents based on their outstanding inhibitory potency against a panel of human cancer cells compared with reference anticancer drugs. These findings encourage medicinal chemists to explore new areas to improve human health and reduce suffering.

Graphical abstract: Anticancer therapeutic potential of benzofuran scaffolds

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Article information

DOI
https://doi.org/10.1039/D3RA01383A
Article type
Review Article
Submitted
01 Mar 2023
Accepted
31 Mar 2023
First published
11 Apr 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 11096-11120

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Anticancer therapeutic potential of benzofuran scaffolds

A. A. Abbas and K. M. Dawood, RSC Adv., 2023, 13, 11096 DOI: 10.1039/D3RA01383A

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