Recognition, detection and host–guest chemistry of hydrogen peroxide in a fluorescent metal–organic framework with chiral helical channels

Hong Cai; Jie-Wen Wu; Xiao-Jun Cai; Zhou Lu; Ya-Liang Lai; Jing-Xuan Sun; Zhuo-Li Yuan; Yang-Ying Huang; Jing-Wen Cai; Wen Lu; Yi-Hong Lu; Hui-Ying Zhang; Dan Li

doi:10.1039/D3QI01092A

Recognition, detection and host–guest chemistry of hydrogen peroxide in a fluorescent metal–organic framework with chiral helical channels†

Hong Cai,

*^a Jie-Wen Wu,^a Xiao-Jun Cai,^a Zhou Lu,

^b Ya-Liang Lai,^c Jing-Xuan Sun,^d Zhuo-Li Yuan,^a Yang-Ying Huang,^a Jing-Wen Cai,^a Wen Lu,^a Yi-Hong Lu,^a Hui-Ying Zhang^a and Dan Li

*^c

Author affiliations

* Corresponding authors

^a School of Chemistry and Environmental Engineering, Hanshan Normal University, Chaozhou 521041, P. R. China
E-mail: tiddychen@163.com

^b Department of Chemistry, University of Rochester, Rochester, New York 14627, USA

^c College of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University, Guangzhou 510632, P. R. China
E-mail: danli@jnu.edu.cn

^d College of Chemistry & Chemical Engineering, Shantou University, Shantou 515063, P. R. China

Abstract

Combining supramolecular chemistry and bioscience, metal–organic frameworks (MOFs) built with biomolecules as ligands possess highly ordered structures and unique pores with accessible metal binding sites and rich interactions to drive molecular recognition processes. In this work, a novel purine-based MOF with chiral helical channels has been successfully constructed, named HSTC-1, which identifies H₂O₂ with a fluorescence quenching effect. Notably, the successful encapsulation of H₂O₂ could be observed by single-crystal X-ray diffraction. Metadynamics and density functional theory calculations reveal that the adsorption of H₂O₂ molecules through the chiral channels induces chiral distribution of subsequent guests to form a host–guest recognition system of H₂O₂@HSTC-1, which slows down the oxidation of the host framework. This work provides unique insights for the construction of intelligent protection matrix materials and is of great significance in the fields of pharmacochemistry and biomedicine.

This article is part of the themed collection: FOCUS: Design and applications of metal-organic frameworks (MOFs)

Inorganic Chemistry Frontiers

Recognition, detection and host–guest chemistry of hydrogen peroxide in a fluorescent metal–organic framework with chiral helical channels†

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Recognition, detection and host–guest chemistry of hydrogen peroxide in a fluorescent metal–organic framework with chiral helical channels

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