Issue 45, 2023
From the journal:

Organic & Biomolecular Chemistry

Genome-driven discovery of new serrawettin W2 analogues from Serratia fonticola DSM 4576†

Haolin Qiu,a   Yang Xiao,a   Ling Shen,a   Tao Han,a   Qiang He,c   Aiying Li,d   Peng Zhanga  and  Xiaofeng Cai ORCID logo *ab  

* Corresponding authors

a School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, People's Republic of China
E-mail: caixiaofeng@hust.edu.cn

b State Key Laboratory of Dao-di Herbs, Beijing 100700, P. R. China

c Xianning Public Inspection Center of Hubei Province, Xianning 437000, P. R. China

d Helmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, P.R. China

Abstract

By expressing a multimodular NRPS gene sefA from Serratia fonticola DSM 4576 in E. coli, four new serrawettin W2 analogues, namely sefopeptides A–D (1–4), were isolated and structurally characterized and their biosynthesis was proposed. A bioactivity assay showed that sefopeptide C (3) exhibits moderate cytotoxic activity against acute promyelocytic leukemia NB4 cells.

Graphical abstract: Genome-driven discovery of new serrawettin W2 analogues from Serratia fonticola DSM 4576

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Article information

DOI
https://doi.org/10.1039/D3OB01642K
Article type
Paper
Submitted
09 Oct 2023
Accepted
27 Oct 2023
First published
31 Oct 2023

Org. Biomol. Chem., 2023,21, 9029-9036

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Genome-driven discovery of new serrawettin W2 analogues from Serratia fonticola DSM 4576

H. Qiu, Y. Xiao, L. Shen, T. Han, Q. He, A. Li, P. Zhang and X. Cai, Org. Biomol. Chem., 2023, 21, 9029 DOI: 10.1039/D3OB01642K

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