Issue 26, 2023
From the journal:

Organic & Biomolecular Chemistry

Synthesis, reactions and application of chalcones: a systematic review

Mona A. Shalaby,a   Sameh A. Rizk ORCID logo a  and  Asmaa M. Fahim ORCID logo *b  

* Corresponding authors

a Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, P.O. 11566, Cairo, Egypt

b Green Chemistry Department, National Research Centre, Dokki, P.O. Box 12622, Cairo, Egypt
E-mail: asmaamahmoud8521@gmail.com, am.abdel-wahid@nrc.sci.eg

Abstract

Chalcones are a group of naturally occurring compounds that have biological effects that include anti-inflammatory, anti-cancer, and antibacterial properties. Current chalcone research, including their synthesis, structure–activity relationships, and biological activities, is summarized herein. Along with their toxicity and safety profiles, the prospective usage of chalcones in medicinal research and development is discussed. This review emphasizes the need for additional research in order to fully examine the therapeutic potential of chalcones as therapeutic agents for the treatment of a variety of disorders.

Graphical abstract: Synthesis, reactions and application of chalcones: a systematic review

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Article information

DOI
https://doi.org/10.1039/D3OB00792H
Article type
Review Article
Submitted
21 May 2023
Accepted
07 Jun 2023
First published
08 Jun 2023

Org. Biomol. Chem., 2023,21, 5317-5346

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Synthesis, reactions and application of chalcones: a systematic review

M. A. Shalaby, S. A. Rizk and A. M. Fahim, Org. Biomol. Chem., 2023, 21, 5317 DOI: 10.1039/D3OB00792H

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