Catalytic aminomethylative etherification of N-allenamides with N,O-acetals enabled by Lewis/Brønsted acid catalysis†
Jiangtao
Sun 
*a
*a
Abstract
A novel copper-catalyzed aminomethylative etherification of N-allenamides/alkoxyallenes with N,O-acetals has been realized under mild reaction conditions, in which every single atom of N,O-acetals is incorporated into the newly formed molecules. Furthermore, in the presence of a chiral phosphoric acid, the asymmetric aminomethylative etherification of N-allenamides has been accomplished using N,O-acetals as bifunctionalization reagents.
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