Issue 20, 2023
From the journal:

Organic & Biomolecular Chemistry

Copper-catalyzed one-pot [3 + 2] cycloadditions of ethynyl indoloxazolidones with 1,3-cyclohexanediones†

Qing-Qiang Su,a   Ruo-Nan Wang,a   Yong-Zheng Lv,a   Ya-Xin Fan,a   Shan Li,a   Hong-Li Huang*a  and  Ji-Yuan Du ORCID logo *a  

* Corresponding authors

a College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, Shandong 252059, China
E-mail: huanghongli@lcu.edu.cn, dujy2015@163.com

Abstract

Fused furans are commonly found units in natural products and medicinal molecules, and methods for their introduction are of fundamental importance. Here we report one-pot cycloadditions of ethynyl indoloxazolidones with 1,3-cyclohexanediones enabled by copper catalysis, leading to a series of functionalized furan derivatives in good yields. This method features mild reaction conditions, high efficiency, and wide substrate scope.

Graphical abstract: Copper-catalyzed one-pot [3 + 2] cycloadditions of ethynyl indoloxazolidones with 1,3-cyclohexanediones

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Article information

DOI
https://doi.org/10.1039/D3OB00332A
Article type
Communication
Submitted
02 Mar 2023
Accepted
21 Apr 2023
First published
24 Apr 2023

Org. Biomol. Chem., 2023,21, 4191-4194

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Copper-catalyzed one-pot [3 + 2] cycloadditions of ethynyl indoloxazolidones with 1,3-cyclohexanediones

Q. Su, R. Wang, Y. Lv, Y. Fan, S. Li, H. Huang and J. Du, Org. Biomol. Chem., 2023, 21, 4191 DOI: 10.1039/D3OB00332A

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