Quantitative determination of the binding capabilities of individual large-ring cyclodextrins in complex mixtures

Dennis Larsen; Andreas Erichsen; Giorgia Masciotta; Sebastian Meier; Sophie R. Beeren

doi:10.1039/D3CC05897B

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Quantitative determination of the binding capabilities of individual large-ring cyclodextrins in complex mixtures†

Dennis Larsen,

^a Andreas Erichsen,

^a Giorgia Masciotta,^a Sebastian Meier

^a and Sophie R. Beeren

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Technical University of Denmark, Kemitorvet 207, DK-2800 Kongens Lyngby, Denmark
E-mail: sopbee@kemi.dtu.dk

Abstract

Large-ring cyclodextrins (CDs) are a comparatively unexplored family of macrocycles. We use high-resolution ¹H–¹³C HSQC NMR experiments to resolve the anomeric signals of at least 13 different size CDs in a mixture. Using a single titration experiment, we can quantify the individual binding capabilites of these structurally-related hosts, avoiding the need for cumbersome isolation.

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Article information

DOI: https://doi.org/10.1039/D3CC05897B
Article type: Communication
Submitted: 02 Dec 2023
Accepted: 23 Jan 2024
First published: 31 Jan 2024

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Chem. Commun., 2024,60, 2090-2093

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Quantitative determination of the binding capabilities of individual large-ring cyclodextrins in complex mixtures

D. Larsen, A. Erichsen, G. Masciotta, S. Meier and S. R. Beeren, Chem. Commun., 2024, 60, 2090 DOI: 10.1039/D3CC05897B

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Chemical Communications

Quantitative determination of the binding capabilities of individual large-ring cyclodextrins in complex mixtures†

Abstract

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Quantitative determination of the binding capabilities of individual large-ring cyclodextrins in complex mixtures

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