Issue 69, 2023
From the journal:

Chemical Communications

Palladium-catalyzed coupling of amides and cyclopropanols for the synthesis of γ-diketones†

Lili Fang,a   Shuqi Jia,a   Shuaixin Fana  and  Jin Zhu ORCID logo *a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210023, China
E-mail: jinz@nju.edu.cn

Abstract

A palladium catalytic method has been developed for the coupling of amides and cyclopropanols to γ-diketones, through simultaneous C–N and C–C activation. Heteroatom ligand exchange and heteroatom-to-carbon ligation mode switching enable the achievement of molecular cross-coupling in an amide N-atom structural context-dependent manner, avoiding any stoichiometric organometallic reagent or base.

Graphical abstract: Palladium-catalyzed coupling of amides and cyclopropanols for the synthesis of γ-diketones

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D3CC02888G
Article type
Communication
Submitted
15 Jun 2023
Accepted
31 Jul 2023
First published
31 Jul 2023

Chem. Commun., 2023,59, 10392-10395

Permissions

Request permissions

Palladium-catalyzed coupling of amides and cyclopropanols for the synthesis of γ-diketones

L. Fang, S. Jia, S. Fan and J. Zhu, Chem. Commun., 2023, 59, 10392 DOI: 10.1039/D3CC02888G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements