Issue 59, 2023
From the journal:

Chemical Communications

Access to distal meta-C–H functionalization of arylmethanesulfonic acid derivatives†

Dasari Srinivas,a   Kurella Mounikaa  and  Gedu Satyanarayana ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology (IIT), Hyderabad, Kandi, Sangareddy – 502284, India
E-mail: gvsatya@chy.iith.ac.in
Fax: +040 2301 6003/32

Abstract

Herein, we report the meta-C–H olefination of arylmethanesulfonates aided by a potentially versatile aliphatic nitrile-directing group under microwave irradiation conditions with fair to very good yields and good to outstanding regioselectivities. Significantly, the protocol showed broad substrate scope including olefin-derived drugs and cyclic olefins. Remarkably, a dual meta-C–H bond was amenable to generating the bis-olefination products.

Graphical abstract: Access to distal meta-C–H functionalization of arylmethanesulfonic acid derivatives

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Article information

DOI
https://doi.org/10.1039/D3CC02260A
Article type
Communication
Submitted
09 May 2023
Accepted
20 Jun 2023
First published
20 Jun 2023

Chem. Commun., 2023,59, 9106-9109

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Access to distal meta-C–H functionalization of arylmethanesulfonic acid derivatives

D. Srinivas, K. Mounika and G. Satyanarayana, Chem. Commun., 2023, 59, 9106 DOI: 10.1039/D3CC02260A

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