Issue 42, 2023
From the journal:

Analytical Methods

Implementation of charged microdroplet-based derivatization of bile acids on a cyclic ion mobility spectrometry-mass spectrometry platform†

Olavs Rāciņša  and  Gabe Nagy ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University of Utah, 315 South 1400 East, Room 2020, Salt Lake City, Utah 84112, USA
E-mail: gabe.nagy@utah.edu

Abstract

Herein, we report the first implementation of charged microdroplet-based derivatization on a commercially-available cyclic ion mobility spectrometry-mass spectrometry platform. We have demonstrated the potential of our approach to improve separability of challenging isomers, but more importantly to rapidly screen derivatization reactions through droplet chemistry. Additionally, the use of cyclic ion mobility separations and tandem mass spectrometry reveals insights into product formation that would be lost with single stage mass spectrometry. Overall, we anticipate broad utility of our methodology owing to the simple design and setup for performing these droplet-based reactions and future work coupling these reactions online with liquid chromatography.

Graphical abstract: Implementation of charged microdroplet-based derivatization of bile acids on a cyclic ion mobility spectrometry-mass spectrometry platform

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Article information

DOI
https://doi.org/10.1039/D3AY01447A
Article type
Communication
Submitted
17 Aug 2023
Accepted
10 Oct 2023
First published
11 Oct 2023

Anal. Methods, 2023,15, 5577-5581

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Implementation of charged microdroplet-based derivatization of bile acids on a cyclic ion mobility spectrometry-mass spectrometry platform

O. Rāciņš and G. Nagy, Anal. Methods, 2023, 15, 5577 DOI: 10.1039/D3AY01447A

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