Nanomaterials for miRNA detection: the hybridization chain reaction strategy

Brij Mohan; Sandeep Kumar; Suresh Kumar; Krunal Modi; Deependra Tyagi; Dimitri Papukashvili; Nino Rcheulishvili; Armando J. L. Pombeiro

doi:10.1039/D2SD00209D

Nanomaterials for miRNA detection: the hybridization chain reaction strategy

Brij Mohan,

*^a Sandeep Kumar,^b Suresh Kumar,

*^c Krunal Modi,

^d Deependra Tyagi,^e Dimitri Papukashvili,^e Nino Rcheulishvili^e and Armando J. L. Pombeiro^a

Author affiliations

* Corresponding authors

^a Centro de Química Estrutural, Institute of Molecular Sciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
E-mail: brizharry17@gmail.com

^b School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China

^c Department of Chemistry, SUS Government PG College, Matak Majri, Karnal, Haryana, India
E-mail: sureshprocha@gmail.com

^d Department of Humanity and Science, School of Engineering, Indrashil University, Mehsana-382740, Gujarat, India

^e Southern University of Science and Technology, Shenzhen 518000, China

Abstract

MicroRNAs (miRNAs) with nucleotides are a class of endogenous small RNAs and can play crucial functions in diagnosing diseases. In particular, the group of miRNAs is responsible for information related to the cell and disease. Among various techniques for miRNA detection, the hybridization chain reaction (HCR) strategy shows potential and efficiency. This review summarizes and studies the most efficient HCR strategy for detecting miRNA using nanomaterials due to their ultrasensitive detection and excellent performances. In addition, signal amplification for the sensitive detection of miRNA due to the chain reaction has been studied. The key factors, such as limit of detection (LOD), linear range, the importance of the strategy, limitations or challenges, and future perspective are described. Finally, the study will provide new findings for developing a miRNA detection strategy applicable to disease diagnosis.

Article information

https://doi.org/10.1039/D2SD00209D

Article type

Critical Review

Submitted

21 Nov 2022

Accepted

07 Dec 2022

First published

08 Dec 2022

This article is Open Access

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Sens. Diagn., 2023,2, 78-89

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Nanomaterials for miRNA detection: the hybridization chain reaction strategy

B. Mohan, S. Kumar, S. Kumar, K. Modi, D. Tyagi, D. Papukashvili, N. Rcheulishvili and A. J. L. Pombeiro, Sens. Diagn., 2023, 2, 78 DOI: 10.1039/D2SD00209D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Sensors & Diagnostics

Nanomaterials for miRNA detection: the hybridization chain reaction strategy

Abstract

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Nanomaterials for miRNA detection: the hybridization chain reaction strategy

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