Issue 27, 2023
From the journal:

RSC Advances

Applications of palladium-catalyzed C–N cross-coupling reactions in pharmaceutical compounds

Reza Emadi,a   Abbas Bahrami Nekoo,b   Fatemeh Molaverdi,c   Zahra Khorsandi, ORCID logo *e   Reza Sheibani*d  and  Hojjat Sadeghi-Aliabadi*e  

* Corresponding authors

a Department of Biochemistry, Institute of Biochemistry & Biophysics (IBB), University of Tehran, Tehran, Iran

b Nanoalvand Pharmaceutical Company, Department of Quality Control, Unit of Raw Materials, Simindasht, Alborz, Iran

c Department of Organic Chemistry, School of Chemistry, College of Science, Tehran University, Tehran, Islamic Republic of Iran

d Amirkabir University of Technology-Mahshahr Campus, University St., Nahiyeh san'ati, Mahshahr, Khouzestan, Iran
E-mail: rsheibani2003@gmail.com

e Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran
E-mail: Sadeghi@pharm.mui.ac.ir

Abstract

C–N cross-coupling bond formation reactions have become valuable approaches to synthesizing anilines and their derivatives, known as important chemical compounds. Recent developments in this field have focused on versatile catalysts, simple operation methods, and green reaction conditions. This review article presents an overview of C–N cross-coupling reactions in pharmaceutical compound synthesis reports. Selected examples of N-arylation reactions of various nitrogen-based compounds and aryl halides are defined for preparing pharmaceutical molecules.

Graphical abstract: Applications of palladium-catalyzed C–N cross-coupling reactions in pharmaceutical compounds

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Article information

DOI
https://doi.org/10.1039/D2RA07412E
Article type
Review Article
Submitted
22 Nov 2022
Accepted
17 May 2023
First published
20 Jun 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 18715-18733

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Applications of palladium-catalyzed C–N cross-coupling reactions in pharmaceutical compounds

R. Emadi, A. Bahrami Nekoo, F. Molaverdi, Z. Khorsandi, R. Sheibani and H. Sadeghi-Aliabadi, RSC Adv., 2023, 13, 18715 DOI: 10.1039/D2RA07412E

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