Electrochemical cyclization of N-cyanamide alkenes with CF3SO2Na to access C,N-(bis)trifluoromethylated cyclic amidines and related compounds†
Wei-Wei
Liao 
*ab
*ab
Abstract
An electrochemical (bis)trifluoromethylative cyclization of N-cyanamide alkenes and alkynes is described, in which commercially available CF3SO2Na and readily available starting materials engaged in a novel electrochemical and sustainable process to assemble (bis)-C,N-trifluoromethylated cyclic amidines, which were previously inaccessible using known methods, with selective multiple bond formations in an undivided cell. Furthermore, this protocol also provided a rapid access to trifluoromethylated azines and amides in a controllable manner. A preliminary mechanism investigation and density functional theory (DFT) calculations were performed which revealed the possible reaction pathway.
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