Issue 6, 2022
From the journal:

Organic Chemistry Frontiers

Lawesson's reagent-promoted deoxygenation of γ-hydroxylactams or succinimides for the syntheses of substituted pyrroles†

Tao Shi, ORCID logo ‡a   Xiaodong Wang,‡a   Gaofeng Yina  and  Zhen Wang ORCID logo *ab  

* Corresponding authors

a School of Pharmacy, Lanzhou University, No 199 West Donggang Road, Lanzhou, China
E-mail: zhenw@lzu.edu.cn

b School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China

Abstract

A new method of Lawesson's reagent-promoted deoxygenation of γ-hydroxypyrrolidones or succinimides was developed for synthesizing substituted pyrroles with 92 examples displayed. This reaction features simple operation, satisfactory yields, wide substrate scope, and excellent functional group tolerance. This robust protocol has been successfully applied in the expeditious syntheses of the key intermediate of Stemona alkaloids.

Graphical abstract: Lawesson's reagent-promoted deoxygenation of γ-hydroxylactams or succinimides for the syntheses of substituted pyrroles

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Article information

DOI
https://doi.org/10.1039/D2QO00013J
Article type
Research Article
Submitted
05 Jan 2022
Accepted
30 Jan 2022
First published
31 Jan 2022

Org. Chem. Front., 2022,9, 1599-1603

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Lawesson's reagent-promoted deoxygenation of γ-hydroxylactams or succinimides for the syntheses of substituted pyrroles

T. Shi, X. Wang, G. Yin and Z. Wang, Org. Chem. Front., 2022, 9, 1599 DOI: 10.1039/D2QO00013J

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