SCHEDULED MAINTENANCE
Enamine-mediated Mannich reaction of cyclic N,O-acetals and amido acetals: the multigram synthesis of pyrrolidine alkaloid precursors†
Andrey V.
Smolobochkin, 
a
Almir S.
Gazizov,
*a
Tanzilya S.
Rizbayeva,
a
Julia K.
Voronina,
cd
Victor V.
Syakaev,
a
a
Almir S.
Gazizov,
*a
Tanzilya S.
Rizbayeva,
a
Julia K.
Voronina,
cd
Victor V.
Syakaev,
a
Abstract
The cooperative L-proline/Brønsted acid/base promoted reaction of 2-ethoxypyrrolidines or N-substituted 4,4-diethoxybutan-1-amines with methyl(alkyl/aryl)ketones for the synthesis of 2-(acylmethylene)pyrrolidine derivatives is reported. The key features of the developed protocol are gram-scale synthesis of the target compounds, easily available starting materials, operational simplicity and usage of non-expensive reagents.
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