Catalyst-free direct regiospecific multicomponent synthesis of C3-functionalized pyrroles†
Eldhose
Iype, 
b
Indresh
Kumar
*a
b
Indresh
Kumar
*a
Abstract
An operationally simple catalyst-free protocol for the direct regiospecific synthesis of β-(C3)-substituted pyrroles has been developed. The enamine intermediate, in situ generated from succinaldehyde and a primary amine, was trapped with activated carbonyls before the Paal–Knorr reaction in a direct multicomponent “just-mix” fashion to furnish pyrroles with overall good yields. Several C3-substituted N-alkyl/aryl/H pyrroles have been produced under open-flask conditions with high atom economy and avoiding protection–deprotection chemistry.
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