Issue 22, 2022

Application of DMSO as a methylthiolating reagent in organic synthesis

Abstract

In the past decades, DMSO has been widely used not only as a common solvent but also as an environmentally benign oxidant in various organic transformations. Most strikingly, DMSO can be used as a sulfur source to construct methylthiolated building blocks of potential biologically active molecules, which is a remarkable achievement in the field of organic sulfur chemistry. The purpose of this review article is to summarize and discuss the main developments in the application of DMSO as a methylthiolating reagent to introduce the –SMe functionality in organic synthesis.

Graphical abstract: Application of DMSO as a methylthiolating reagent in organic synthesis

Article information

Article type
Review Article
Submitted
26 Mar 2022
Accepted
03 May 2022
First published
03 May 2022

Org. Biomol. Chem., 2022,20, 4471-4495

Application of DMSO as a methylthiolating reagent in organic synthesis

X. Li, X. Wang, Y. Li, J. Xiao and Y. Du, Org. Biomol. Chem., 2022, 20, 4471 DOI: 10.1039/D2OB00570K

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