SCHEDULED MAINTENANCE
Difurofuranoids A–F: six unprecedented furofuran lignan dimers from Forsythia suspensa†
Ya-Nan
Yang, 
a
Pei-Cheng
Zhang
*a
a
Pei-Cheng
Zhang
*a
Abstract
Difurofuranoids A–F (1–6), six novel furofuran lignan dimers that were polymerized through the unusual connection of C5–C5′′, were isolated from the fruits of Forsythia suspensa. Their structures, including the absolute configurations, were deduced by extensive spectroscopic analysis (UV, IR, NMR, and HR-ESI-MS) and quantum chemical calculations. Compounds 2, 4, and 5 showed more significant hepatoprotective activities than the positive control drug (bicyclol) at a concentration of 10 μM (p < 0.01).
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