Issue 9, 2022
From the journal:

Green Chemistry

Efficient synthesis of 2,6-bis(hydroxymethyl)pyridine using whole-cell biocatalysis†

Tsvetan Kardashliev,*a   Sven Pankea  and  Martin Held ORCID logo *a  

* Corresponding authors

a Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland
E-mail: tsvetank@ethz.ch, heldma@ethz.ch

Abstract

We demonstrate a novel one-pot biocatalytic process for the preparation of a versatile chemical intermediate, 2,6-bis(hydroxymethyl)pyridine, from naturally-occurring 2,6-lutidine using recombinant microbial whole cells as a catalysts. After scale up, the bioconversion enabled titers exceeding 12 g L−1 with a space–time yield of 0.8 g L−1 h−1. This biocatalytic route offers a simpler and more sustainable alternative to multistep organic synthesis protocols.

Graphical abstract: Efficient synthesis of 2,6-bis(hydroxymethyl)pyridine using whole-cell biocatalysis

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Article information

DOI
https://doi.org/10.1039/D2GC00333C
Article type
Communication
Submitted
24 Jan 2022
Accepted
08 Apr 2022
First published
21 Apr 2022
This article is Open Access
Creative Commons BY-NC license

Green Chem., 2022,24, 3651-3654

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Efficient synthesis of 2,6-bis(hydroxymethyl)pyridine using whole-cell biocatalysis

T. Kardashliev, S. Panke and M. Held, Green Chem., 2022, 24, 3651 DOI: 10.1039/D2GC00333C

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