Issue 3, 2023
From the journal:

Food & Function

Cinnamon (Cinnamomum cassia) water extract improves diarrhea symptoms by changing the gut environment: a randomized controlled trial†

Soo-yeon Park,a   Yong Dae Kim,a   Min Seo Kim,a   Ki-Tae Kimb  and  Ji Yeon Kim ORCID logo *a  

* Corresponding authors

a Department of Food Science and Technology, Seoul National University of Science and Technology, Seoul 01811, Republic of Korea
E-mail: jiyeonk@seoultech.ac.kr
Fax: +82-2-976-6460
Tel: +82-2-970-6740

b Department of Korean Internal Medicine, College of Korean Medicine, Semyung University, Jecheon 27136, Republic of Korea

Abstract

Cinnamon is a spice obtained from the bark of Cinnamomum and contains anti-inflammatory ingredients such as coumarin, cinnamaldehyde, and cinnamic acid. This study evaluated the effect of cinnamon water extract (CWE) on the symptoms of subjects with diarrhea in an 8-week randomized controlled trial. Seventy subjects with diarrhea symptoms were randomized and received three capsules of 400 mg CWE or placebo twice daily for 8 weeks. CWE intake significantly increased colonic transit time (p = 0.019) and fecal isobutyric acid (p = 0.008) and spermidine (p = 0.009) contents compared to placebo intake. In contrast, CWE decreased fecal indole (p = 0.032) and agmatine (p = 0.018) contents. Gut microbiota analysis showed increased alpha diversity and significant changes in strains such as Bifidobacterium longum ATCC 55813 (LDA = 1.38) in the CWE group compared with the placebo group. Bifidobacterium longum ATCC 55813 showed a positive correlation with colon transit time and stool phenol and spermidine contents. CWE improved diarrhea symptoms and changed the composition of stools and the gut microbiota. These results indicate that cinnamon intake relieves diarrhea symptoms through metabolic changes due to changes in intestinal microbial groups.

Graphical abstract: Cinnamon (Cinnamomum cassia) water extract improves diarrhea symptoms by changing the gut environment: a randomized controlled trial

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Article information

DOI
https://doi.org/10.1039/D2FO01835G
Article type
Paper
Submitted
29 Jun 2022
Accepted
11 Jan 2023
First published
19 Jan 2023
This article is Open Access
Creative Commons BY-NC license

Food Funct., 2023,14, 1520-1529

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Cinnamon (Cinnamomum cassia) water extract improves diarrhea symptoms by changing the gut environment: a randomized controlled trial

S. Park, Y. D. Kim, M. S. Kim, K. Kim and J. Y. Kim, Food Funct., 2023, 14, 1520 DOI: 10.1039/D2FO01835G

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