Supramolecular coordination complexes (SCCs) with aggregation-induced emission for in vitro photodynamic therapy

Haiqi Jia; Tingyu Shi; Tian He; Yang Li; Shouchun Yin

doi:10.1039/D2DT03855B

Supramolecular coordination complexes (SCCs) with aggregation-induced emission for in vitro photodynamic therapy†

Haiqi Jia,^a Tingyu Shi,^a Tian He,^a Yang Li*^a and Shouchun Yin

*^ab

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* Corresponding authors

^a Key Laboratory of Organosilicon Chemistry and Materials Technology of Ministry of Education, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang Province, China
E-mail: liyang@hznu.edu.cn, yinsc@hznu.edu.cn

^b Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, School of Science, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China

Abstract

Photodynamic therapy (PDT) has attracted a great deal of attention in the field of cancer treatment due to its non-invasive nature, high repeatability and minimal side effects. Due to the dual effect of organic small molecule donors and platinum receptors, supramolecular coordination complexes (SCCs) exhibit stronger reactive oxygen species (ROS) production capacity and have become a promising class of photosensitizers (PSs). Herein, we report a rhomboid SCC MD-CN based on the D–A structure with aggregation-induced emission (AIE). The results show that the as-prepared nanoparticles (NPs) had excellent photosensitization efficiency and good biocompatibility. Most importantly, they exhibited potential killing effects on cancer cells in vitro under light irradiation.

This article is part of the themed collection: Spotlight Collection: Aggregation induced luminescence of metal complexes

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DOI: https://doi.org/10.1039/D2DT03855B
Article type: Communication
Submitted: 30 Nov 2022
Accepted: 16 Mar 2023
First published: 24 Mar 2023

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Dalton Trans., 2023,52, 4296-4302

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Supramolecular coordination complexes (SCCs) with aggregation-induced emission for in vitro photodynamic therapy

H. Jia, T. Shi, T. He, Y. Li and S. Yin, Dalton Trans., 2023, 52, 4296 DOI: 10.1039/D2DT03855B

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Supramolecular coordination complexes (SCCs) with aggregation-induced emission for in vitro photodynamic therapy†

Abstract

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Supramolecular coordination complexes (SCCs) with aggregation-induced emission for in vitro photodynamic therapy

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