Synthesis of carbon-11 radiolabelled transition metal complexes using 11C-dithiocarbamates

Sara Cesarec; Fraser Edgar; Titan Lai; Christophe Plisson; Andrew J. P. White; Philip W. Miller

doi:10.1039/D2DT00266C

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Synthesis of carbon-11 radiolabelled transition metal complexes using ¹¹C-dithiocarbamates†

Sara Cesarec,

^a Fraser Edgar,^ab Titan Lai,^a Christophe Plisson,^c Andrew J. P. White

^a and Philip W. Miller

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London, UK
E-mail: philip.miller@imperial.ac.uk

^b School of Biomedical Engineering and Imaging Sciences, King's College London, 4th Floor Lambeth Wing, St Thomas’ Hospital, London, UK

^c Invicro, Burlington Danes Building, Hammersmith Hospital, Du Cane Road, London, UK

Abstract

A novel radiolabelling method exploiting ¹¹C-dithiocarbamate ligands has been used to generate ¹¹C-labelled Au(I), Au(III), Pd(II) and Pt(II) complexes in high radiochemical yields (71–99%). Labelled complexes were prepared in a rapid one-pot procedure via the substitution reaction of ¹¹C-dithiocarbamate ligands with appropriate transition metal chloride precursors.

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Article information

DOI: https://doi.org/10.1039/D2DT00266C
Article type: Communication
Submitted: 27 Jan 2022
Accepted: 01 Mar 2022
First published: 10 Mar 2022
This article is Open Access

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Dalton Trans., 2022,51, 5004-5008

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Synthesis of carbon-11 radiolabelled transition metal complexes using ¹¹C-dithiocarbamates

S. Cesarec, F. Edgar, T. Lai, C. Plisson, A. J. P. White and P. W. Miller, Dalton Trans., 2022, 51, 5004 DOI: 10.1039/D2DT00266C

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Dalton Transactions