Catalytic O2 activation toward oxidative N–S bond formation by a thiolato Fe(iii) complex†
Abstract
Compounds with the benzisothiazol-3-one (BIT) skeleton perform excellently in the pharmaceutical field, although current synthetic methods remain limited in terms of synthetic efficiency. Herein, we report the catalytic intramolecular N–S bond formation for BITs from easily prepared disulfide precursors by an Fe(III) dithiolate through O2 activation at 298 K. Interestingly, the catalytic performance is enhanced by substituting O2 with a milder O-donor oxidant, ONMe3. Catalytic oxygenation of PPh3 to OPPh3 can also proceed under similar conditions. In addition, the first anionic monosulfenato Fe(III) species, Fe(III)–S(![[double bond, length as m-dash]](https://www.rsc.org/images/entities/char_e001.gif)
O)R, is isolated with structural characterization from the reaction of Fe(III) thiolate and ONMe3.
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