Issue 60, 2022
From the journal:

Chemical Communications

Ascorbate-assisted nitric oxide release from photocontrollable nitrosonium ion releasers for potent ex vivo photovasodilation†

Naoya Ieda,*a   Yuka Yoshikawa,a   Natsumi Tomita,a   Kei Ohkubo, ORCID logo b   Yuji Hotta,a   Mitsuyasu Kawaguchi,a   Kazunori Kimuraa  and  Hidehiko Nakagawa ORCID logo *a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1, Tanabe-dori, Mizuho-ku, Nagoya, Aichi, Japan
E-mail: ieda@phar.nagoya-cu.ac.jp, deco@phar.nagoya-cu.ac.jp

b Institute for Open and Transdisciplinary Research Initiatives & Institute for Advanced Co-Creation Studies, Osaka University, 1-6 Yamada-oka, Suita, Osaka, Japan

Abstract

We found that N-nitrosoaminoanisole derivatives tethered to dyes work as photocontrollable nitrosonium cation releasers and are converted to potent nitric oxide releasers in the presence of sodium ascorbate. The N-nitrosoaminoanisole derivative 2 worked as a more potent photovasodilating reagent ex vivo than previously reported nitric oxide releasers.

Graphical abstract: Ascorbate-assisted nitric oxide release from photocontrollable nitrosonium ion releasers for potent ex vivo photovasodilation

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Article information

DOI
https://doi.org/10.1039/D2CC03193K
Article type
Communication
Submitted
07 Jun 2022
Accepted
22 Jun 2022
First published
07 Jul 2022
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2022,58, 8420-8423

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Ascorbate-assisted nitric oxide release from photocontrollable nitrosonium ion releasers for potent ex vivo photovasodilation

N. Ieda, Y. Yoshikawa, N. Tomita, K. Ohkubo, Y. Hotta, M. Kawaguchi, K. Kimura and H. Nakagawa, Chem. Commun., 2022, 58, 8420 DOI: 10.1039/D2CC03193K

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