Issue 5, 2022
From the journal:

RSC Chemical Biology

The chemistry and biology of natural ribomimetics and related compounds

Takeshi Tsunoda, ORCID logo a   Samuel Tanoeyadi,a   Philip J. Proteaua  and  Taifo Mahmud ORCID logo *a  

* Corresponding authors

a Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331, USA
E-mail: Taifo.Mahmud@oregonstate.edu

Abstract

Natural ribomimetics represent an important group of specialized metabolites with significant biological activities. Many of the activities, e.g., inhibition of seryl-tRNA synthetases, glycosidases, or ribosomes, are manifestations of their structural resemblance to ribose or related sugars, which play roles in the structural, physiological, and/or reproductive functions of living organisms. Recent studies on the biosynthesis and biological activities of some natural ribomimetics have expanded our understanding on how they are made in nature and why they have great potential as pharmaceutically relevant products. This review article highlights the discovery, biological activities, biosynthesis, and development of this intriguing class of natural products.

Graphical abstract: The chemistry and biology of natural ribomimetics and related compounds

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Article information

DOI
https://doi.org/10.1039/D2CB00019A
Article type
Review Article
Submitted
21 Jan 2022
Accepted
06 Apr 2022
First published
07 Apr 2022
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2022,3, 519-538

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The chemistry and biology of natural ribomimetics and related compounds

T. Tsunoda, S. Tanoeyadi, P. J. Proteau and T. Mahmud, RSC Chem. Biol., 2022, 3, 519 DOI: 10.1039/D2CB00019A

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