Layer-by-layer assembly methods and their biomedical applications

Zhuying Zhang; Jinfeng Zeng; Jürgen Groll; Michiya Matsusaki

doi:10.1039/D2BM00497F

Layer-by-layer assembly methods and their biomedical applications

Zhuying Zhang,^a Jinfeng Zeng,^ab Jürgen Groll

^c and Michiya Matsusaki

*^ad

Author affiliations

* Corresponding authors

^a Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan
E-mail: m-matsus@chem.eng.osaka-u.ac.jp

^b Research Fellow of Japan Society for the Promotion of Science, Kojimachi Business Center Building, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan

^c Department of Functional Materials in Medicine and Dentistry at the Institute of Functional Materials and Biofabrication (IFB) and Bavarian Polymer Institute (BPI), University of Würzburg, Pleicherwall 2, 97070 Würzburg, Germany

^d Joint Research Laboratory (TOPPAN) for Advanced Cell Regulatory Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan

Abstract

Layer-by-layer (LbL) assembly has attracted much interest because of its ability to provide nanoscale control over film characteristics and because of a wide choice of available materials. The methods of LbL not only determine the process properties, but also directly affect film properties. In this review, we will discuss LbL methodologies that have been used in biomedical fields. Special attention is devoted to different properties arising from methods that allow for diverse biomedical applications, ranging from surface modification to tissue engineering. We conclude with a discussion of the current challenges and future perspectives.

Article information

https://doi.org/10.1039/D2BM00497F

Article type

Review Article

Submitted

01 Apr 2022

Accepted

22 Jun 2022

First published

23 Jun 2022

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Biomater. Sci., 2022,10, 4077-4094

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Layer-by-layer assembly methods and their biomedical applications

Z. Zhang, J. Zeng, J. Groll and M. Matsusaki, Biomater. Sci., 2022, 10, 4077 DOI: 10.1039/D2BM00497F

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Biomaterials Science

Layer-by-layer assembly methods and their biomedical applications

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Layer-by-layer assembly methods and their biomedical applications

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